Astaxanthin supplementation impacts the cellular HSP expression profile during passive heating

Astaxanthin is a powerful carotenoid antioxidant prevalent in marine organisms and approved as a food supplement. Recent studies have demonstrated Astaxanthin’s beneficial attributes in various health states. Following initial reports of potential heat protective properties in Astaxanthin supplement...

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Bibliographic Details
Published in:Cell stress & chaperones 2020-05, Vol.25 (3), p.549-561
Main Authors: Fleischmann, Chen, Bar-Ilan, Netta, Horowitz, Michal, Bruchim, Yaron, Deuster, Patricia, Heled, Yuval
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Astaxanthin
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell Biology
Dietary supplements
Heat shock
Heat stress
Heat tolerance
Heat-Shock Proteins - metabolism
Heat-Shock Response - drug effects
Hsp27 protein
Hsp72 protein
Immunology
Liver - metabolism
Male
Marine organisms
Myocardium - metabolism
Neurosciences
Oils & fats
Oleoresins
Olive oil
Rats, Sprague-Dawley
SHORT COMMUNICATION
Xanthophylls - pharmacology
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Summary:Astaxanthin is a powerful carotenoid antioxidant prevalent in marine organisms and approved as a food supplement. Recent studies have demonstrated Astaxanthin’s beneficial attributes in various health states. Following initial reports of potential heat protective properties in Astaxanthin supplemented rats, we present here results of a novel study examining the effect of Astaxanthin supplementation on the heat shock response in rats in relation to core temperature (Tc) and the ensuing physiological strain. Two hours of heat stress at 41 °C during which rats developed their thermoregulatory hyperthermic plateau resulted in progressive increases in HSP72 and HSP27 in the Astaxanthin (Oleoresin)-treated group but not in the control (Olive oil) group. Enhanced elevation in HSPs suggests that Astaxanthin supplementation may augment the cellular stress protective response to heat stress.
ISSN:1355-8145
1466-1268
DOI:10.1007/s12192-019-01061-4