miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5

Ovarian cancer is the second most common gynaecological malignancy, and microRNAs (miRNAs) play important role in the cancer development. Here, we found that the level of miR-200b/200a/429 was significantly increased in serum and tumor tissues of patients with stage-I ovarian cancer. Consistent with...

Full description

Saved in:
Bibliographic Details
Published in:Journal of oncology 2020, Vol.2020 (2020), p.1-8
Main Authors: Zou, Hua, Lee, Jin-Won, Chun, Wan Joo, Huang, Ping, Cui, Huiling, Guan, Wei, Kim, Heasung
Format: Article
Language:English
Subjects:
Cancer
Carboplatin
Cell culture
Cell growth
Comparative analysis
Development and progression
Diagnosis
Experiments
Gene expression
Metastasis
MicroRNA
MicroRNAs
Ovarian cancer
Patients
Protein expression
Proteins
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ovarian cancer is the second most common gynaecological malignancy, and microRNAs (miRNAs) play important role in the cancer development. Here, we found that the level of miR-200b/200a/429 was significantly increased in serum and tumor tissues of patients with stage-I ovarian cancer. Consistent with these results, we detected increased expression levels of miR-200b/200a/429 in ovarian cancer cell lines compared with the human nontumorigenic ovarian epithelial cell line T80. The overexpression of miR-200b/200a/429 in T80 cells stimulated proliferation and caused their growth in soft agar and tumor formation in nude mice. Furthermore, we determined that miR-200b/200a/429 targets inhibitor of growth family 5 (ING5) and that the overexpression of ING5 can block miR-200b/200a/429-induced T80 cell transformation and tumorigenesis. Our findings suggest that miR-200b/200a/429 may be a useful biomarker for the early detection of ovarian cancer and that miR-200b/200a/429 significantly contributes to ovarian cancer development through ING5.
ISSN:1687-8450
1687-8450
1687-8469
DOI:10.1155/2020/3404059