Alcohol and Tobacco Use in Relation to Mammographic Density in 23,456 Women

Percent density (PD) is a strong risk factor for breast cancer that is potentially modifiable by lifestyle factors. PD is a composite of the dense (DA) and nondense (NDA) areas of a mammogram, representing predominantly fibroglandular or fatty tissues, respectively. Alcohol and tobacco use have been...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-05, Vol.29 (5), p.1039-1048
Main Authors: McBride, Russell B, Fei, Kezhen, Rothstein, Joseph H, Alexeeff, Stacey E, Song, Xiaoyu, Sakoda, Lori C, McGuire, Valerie, Achacoso, Ninah, Acton, Luana, Liang, Rhea Y, Lipson, Jafi A, Yaffe, Martin J, Rubin, Daniel L, Whittemore, Alice S, Habel, Laurel A, Sieh, Weiva
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Breast - diagnostic imaging
Breast - physiopathology
Breast Density
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
Breast Neoplasms - physiopathology
Breast Neoplasms - prevention & control
Cohort Studies
Female
Humans
Mammography - statistics & numerical data
Middle Aged
Risk Assessment - statistics & numerical data
Risk Factors
Tobacco Smoking - adverse effects
Tobacco Smoking - epidemiology
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Summary:Percent density (PD) is a strong risk factor for breast cancer that is potentially modifiable by lifestyle factors. PD is a composite of the dense (DA) and nondense (NDA) areas of a mammogram, representing predominantly fibroglandular or fatty tissues, respectively. Alcohol and tobacco use have been associated with increased breast cancer risk. However, their effects on mammographic density (MD) phenotypes are poorly understood. We examined associations of alcohol and tobacco use with PD, DA, and NDA in a population-based cohort of 23,456 women screened using full-field digital mammography machines manufactured by Hologic or General Electric. MD was measured using Cumulus. Machine-specific effects were estimated using linear regression, and combined using random effects meta-analysis. Alcohol use was positively associated with PD ( = 0.01), unassociated with DA ( = 0.23), and inversely associated with NDA ( = 0.02) adjusting for age, body mass index, reproductive factors, physical activity, and family history of breast cancer. In contrast, tobacco use was inversely associated with PD ( = 0.0008), unassociated with DA ( = 0.93), and positively associated with NDA (
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-19-0348