Translational impact of NIH-funded nonhuman primate research in transplantation

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune respo...

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Bibliographic Details
Published in:Science translational medicine 2019-07, Vol.11 (500), p.1
Main Authors: Knechtle, Stuart J, Shaw, Julia M, Hering, Bernhard J, Kraemer, Kristy, Madsen, Joren C
Format: Article
Language:English
Subjects:
Animal models
Animals
Chimerism
Clinical trials
Humans
Immune response
Immunologic Memory
Immunotherapy
Islet cells
Lung transplantation
National Institutes of Health (U.S.)
Pancreas transplantation
Pancreatic islet transplantation
Primates
Translational Research, Biomedical
Transplantation
United States
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Summary:The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
ISSN:1946-6234
1946-6242
1946-6242
1946-3242
DOI:10.1126/scitranslmed.aau0143