Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

Abstract A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane...

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Bibliographic Details
Published in:The Journal of infectious diseases 2020-06, Vol.222 (1), p.34-37
Main Authors: Zhang, Yonghong, Qin, Ling, Zhao, Yan, Zhang, Ping, Xu, Bin, Li, Kang, Liang, Lianchun, Zhang, Chi, Dai, Yanchao, Feng, Yingmei, Sun, Jianping, Hu, Zhongjie, Xiang, Haiping, Knight, Julian C, Dong, Tao, Jin, Ronghua
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Alleles
Betacoronavirus - genetics
Cohort Studies
Coronavirus Infections - genetics
Coronavirus Infections - virology
Coronaviruses
COVID-19
Female
Genetic diversity
Genotype
High-Throughput Nucleotide Sequencing
Homozygote
Hospitalization
Humans
Interferon
Major and Brief Reports
Male
Membrane Proteins - genetics
Middle Aged
Pandemics
Pneumonia, Viral - genetics
Pneumonia, Viral - virology
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
RNA-Binding Proteins - genetics
SARS-CoV-2
Severity of Illness Index
Transmembrane proteins
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Summary:Abstract A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals. We report evidence of an age-dependent allelic association between interferon-induced transmembrane protein 3 (rs12252 allele) and severity of coronavirus disease 2019, highlighting the need for further studies and the potential for a personalized, genotype-based approach to identifying high-risk individuals.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa224