Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort

Little is known about sex- and age-specific variations and temporal trends in serum uric acid (SUA) concentrations, the prevalence of hyperuricemia and its association with metabolic risk factors in the general population. Between January 1, 1985 and June 30, 2005 146,873 participants (42% women) we...

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Bibliographic Details
Published in:Scientific reports 2020-05, Vol.10 (1), p.7578-7578, Article 7578
Main Authors: Zitt, Emanuel, Fischer, Anton, Lhotta, Karl, Concin, Hans, Nagel, Gabriele
Format: Article
Language:English
Subjects:
692/1807
692/4022
692/499
Adult
Age
Age Factors
Aged
Austria - epidemiology
Biomarkers
Female
g-Glutamyltransferase
Humanities and Social Sciences
Humans
Hypertriglyceridemia
Hyperuricemia
Hyperuricemia - blood
Hyperuricemia - epidemiology
Male
Metabolism
Middle Aged
multidisciplinary
Population Surveillance
Prevalence
Risk Factors
Science
Science (multidisciplinary)
Sex
Sex Factors
Trends
Uric acid
Uric Acid - blood
Women
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Summary:Little is known about sex- and age-specific variations and temporal trends in serum uric acid (SUA) concentrations, the prevalence of hyperuricemia and its association with metabolic risk factors in the general population. Between January 1, 1985 and June 30, 2005 146,873 participants (42% women) were recruited. Prevalence of hyperuricemia was estimated applying a common (SUA > 360 µmol/L) and sex-specific cut-off points (women > 340 µmol/L, men > 420 µmol/L). At baseline, mean age was 41.2 years in men and 51.5 years in women, mean SUA concentration was 314.8 µmol/L and 243.6 µmol/L, respectively. Applying a common cut-off point, the prevalence of hyperuricemia was 18.5% in men and 4.4% in women and by sex-specific cut-off points it was 15.1% and 13.8%, respectively. SUA levels increased by 6.7 µmol/L per decade in men, but remained constant in women until the age of 50 years with a sharp increase by approximately 22 µmol/L per decade thereafter. In men and women, hyperuricemia was associated with obesity, hypertriglyceridemia and elevated gamma-glutamyl transferase. With increasing age SUA levels and the prevalence of hyperuricemia rise in a sex-specific manner. Above the age of 65 years, the sex-specific prevalence of hyperuricemia in women outreaches that in men.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-64587-z