M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis

Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi . Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1...

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Bibliographic Details
Published in:Mycopathologia (1975) 2020-06, Vol.185 (3), p.477-483
Main Authors: Barboza, Tania Cristina, Sotto, Mirian Nacagami, Kanashiro-Galo, Luciane, de Brito, Arival Cardoso, Duarte, Maria Irma Seixas, Quaresma, Juarez Antonio Simões, Pagliari, Carla
Format: Article
Language:English
Subjects:
Arginase
Biomedical and Life Sciences
c-Maf protein
CD163 antigen
Cytokines
Ethylenediaminetetraacetic acid
Eukaryotic Microbiology
Health aspects
Immune response
Immunohistochemistry
Immunomodulation
Lesions
Life Sciences
Lymphocytes T
Macrophages
Medical Microbiology
Microbial Ecology
Microbicides
Microbiology
Mycoses
Mycosis
Nitric-oxide synthase
Original
Original Article
Phenotypes
Plant Sciences
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Summary:Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi . Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-020-00450-z