Metabolites from the marine-facultative Aspergillus sp. MEXU 27854 and Gymnoascus hyalinosporus MEXU 29901 from Caleta Bay, Mexico

[Display omitted] •New N-methyl cyclic pentapeptide and alternariol glucoside.•Marine-facultative fungi from an unexplored area of Mexico.•Absolute configuration by spectrometric analysis and chemical degradation.•Cytotoxic, antimicrobial and phytogrowth inhibition activities. During our ongoing res...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2019-06, Vol.60 (25), p.1649-1652
Main Authors: Aparicio-Cuevas, Manuel A., González, María del Carmen, Raja, Huzefa A., Rivero-Cruz, Isabel, Kurina, Steven J., Burdette, Joanna E., Oberlies, Nicholas H., Figueroa, Mario
Format: Article
Language:English
Subjects:
Ascomycetes
Aspergillus
chemical degradation
chemical structure
Fungi
glucosides
Gymnoascus
Metabolites
Mexico
organic compounds
spectral analysis
tandem mass spectrometry
Unexplored
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •New N-methyl cyclic pentapeptide and alternariol glucoside.•Marine-facultative fungi from an unexplored area of Mexico.•Absolute configuration by spectrometric analysis and chemical degradation.•Cytotoxic, antimicrobial and phytogrowth inhibition activities. During our ongoing research on fungal strains from unexplored sources, the reinvestigation of the CHCl3−MeOH extract of the marine-facultative Aspergillus sp. MEXU 27854 yielded a new N-methyl cyclic pentapeptide (1) along with known butyrolactone II and PF1233 A. In addition, from the marine-facultative Gymnoascus hyalinosporus MEXU 29901, a new alternariol glucoside, 10-O-[β-d-(4-methoxyl-glucopyranosyl)]-4-O-methylalternariol (2) and known alternariol 4-O-methyl ether, alternariol and beauvericin, were isolated. The structures of 1 and 2 were established by detailed spectroscopic data, and their absolute configuration was ascertained by Marfey’s analysis and HRESIMS-MS/MS data for 1, and by chemical degradation and optical rotation analysis for 2.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2019.05.037