MON-113 The Effect of Body Mass Index on the Peak Growth Hormone Level After Growth Hormone Stimulation Test in Children with Short Stature

Objective: The aim of this study is to evaluate the effect of body mass index (BMI) on peak growth hormone (GH) response after GH stimulation test in children with short stature. Methods: Data was obtained from retrospective review of medical records who visited the pediatric endocrinology at St. Vi...

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Bibliographic Details
Published in:Journal of the Endocrine Society 2020-05, Vol.4 (Supplement_1)
Main Authors: Lee, Nayeong, Cho, Wonkyoung, Lee, Yoonji, Kim, Seulki, Lee, Seonhwa, Choi, Yujung, Ahn, Moon Bae, Kim, Shinhee, Cho, Kyoungsoon, Jung, Min-Ho, Suh, Byung-kyu
Format: Article
Language:English
Subjects:
Pediatric Endocrinology
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Summary:Objective: The aim of this study is to evaluate the effect of body mass index (BMI) on peak growth hormone (GH) response after GH stimulation test in children with short stature. Methods: Data was obtained from retrospective review of medical records who visited the pediatric endocrinology at St. Vincent hospital of catholic university for short stature from January 2010 to June 2019. We studied 115 children (aged 3-17 years old) whose height was less than 3percentile for one’s age and sex and who underwent GH stimulation test {GH deficiency (GHD) = 47, Idiopathic short stature (ISS) = 68)}. Peak GH response was stimulated by dopamine (n=111), clonidine (n=7), glucagon (n=19), insulin (n=56) and arginine (n=32). Birth weight, parental height, chronologic age, bone age, height SDS (standard deviation score), weight SDS, BMI SDS hemoglobin, fT4, T3 TSH, cortisol, ACTH, GH, IGF-1 SDS, IGF-BP3 SDS and peak stimulated GH were analyzed. Results: In the characteristics of subject, weight SDS and BMI SDS in GHD group were increased than ISS group (p
ISSN:2472-1972
2472-1972
DOI:10.1210/jendso/bvaa046.1014