A biomimetic peptide recognizes and traps bacteria in vivo as human defensin-6

Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously threatening human health. Here, we design a human defensin-6 mimic peptide (HDMP) that inhibits bacterial invasion in vivo through mimicking the mechanisms of human defensin-6 wi...

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Bibliographic Details
Published in:Science advances 2020-05, Vol.6 (19), p.eaaz4767
Main Authors: Fan, Yu, Li, Xiang-Dan, He, Ping-Ping, Hu, Xiao-Xue, Zhang, Kuo, Fan, Jia-Qi, Yang, Pei-Pei, Zheng, Hao-Yan, Tian, Wen, Chen, Zi-Ming, Ji, Lei, Wang, Hao, Wang, Lei
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Applied Sciences and Engineering
Bacteria
Biomimetics
Defensins - pharmacology
Humans
Ligands
Materials Science
Methicillin-Resistant Staphylococcus aureus
Mice
SciAdv r-articles
Vancomycin - pharmacology
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Summary:Using broad-spectrum antibiotics for microbial infection may cause flora disequilibrium, drug-resistance, etc., seriously threatening human health. Here, we design a human defensin-6 mimic peptide (HDMP) that inhibits bacterial invasion in vivo through mimicking the mechanisms of human defensin-6 with high efficiency and precision. The HDMP with ligand and self-assembling peptide sequence recognizes bacteria through ligand-receptor interactions and subsequently traps bacteria by an in situ adaptive self-assembly process and resulting nanofibrous networks; these trapped bacteria are unable to invade host cells. In four animal infection models, the infection rate was markedly decreased. Notably, administration of HDMP (5 mg/kg) nanoparticles increased the survival rate of mice with methicillin-resistant bacteremia by as much as 100%, even more than that of vancomycin treatment (5 mg/kg, 83.3%)-treated group, the golden standard of antibiotics. This biomimetic peptide shows great potential as a precise and highly efficient antimicrobial agent.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.aaz4767