Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2

Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underl...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-12
Main Authors: Fang, Lin, Deng, Yijun, Hu, Jiashu, Hua, Kaiyao, Xie, Dan, Song, Hongming, Wu, Tianqi, Ji, Changle
Format: Article
Language:English
Subjects:
Adult
Aged
AKT protein
Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Biomarkers
Biotechnology
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer therapies
Cell adhesion & migration
Cell growth
Cell migration
Cell Movement
Cell Proliferation
Chemotherapy
Comparative analysis
Development and progression
Female
Gene expression
Health aspects
Humans
Immunoglobulins
MCF-7 Cells
Metastases
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miRNA
Molecular modelling
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
RNA, Neoplasm - genetics
RNA, Neoplasm - metabolism
Signal transduction
Tumor cell lines
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Summary:Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. In this study, we found that the expression of miR-30b-5p was upregulated in breast cancer tissues and breast cancer cell lines, compared to paracancer tissues and normal breast cell lines. Moreover, induced overexpression of miR-30b-5p promoted the MDA-MB-231 and HCC 1937 cell growth, migration, and invasion and reduced the cellular apoptosis. Further studies confirmed that miR-30b-5p could directly target ASPP2 and then activate the AKT signaling pathway. Our results suggested that miR-30b-5p could act as a tumor promoter in TNBC. The newly identified miR-30b-5p/ASPP2/AKT axis represents a novel therapeutic strategy for treating TNBC.
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/7907269