Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

ABSTRACT In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal...

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Bibliographic Details
Published in:Journal of orthopaedic research 2020-04, Vol.38 (4), p.708-718
Main Authors: Kaji, Deepak A., Tan, Zhijia, Johnson, Gemma L., Huang, Wesley, Vasquez, Kaetlin, Lehoczky, Jessica A., Levi, Benjamin, Cheah, Kathryn S. E., Huang, Alice H.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell Plasticity
Disease
heterotopic ossification
Humans
mesenchymal plasticity
Musculoskeletal Development
Myositis Ossificans - genetics
Ossification, Heterotopic - etiology
Regeneration
transdifferentiation
Wounds and Injuries - complications
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Summary:ABSTRACT In this review, we highlight themes from a recent workshop focused on “Plasticity of Cell Fate in Musculoskeletal Tissues” held at the Orthopaedic Research Society's 2019 annual meeting. Experts in the field provided examples of mesenchymal cell plasticity during normal musculoskeletal development, regeneration, and disease. A thorough understanding of the biology underpinning mesenchymal cell plasticity may offer a roadmap for promoting regeneration while attenuating pathologic differentiation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:708‐718, 2020
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.24523