Progress in the application of organoids to breast cancer research

Breast cancer is the most common cancer diagnosed in women. Breast cancer research is currently based mainly on animal models and traditional cell culture. However, the inherent species gap between humans and animals, as well as differences in organization between organs and cells, limits research a...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-05, Vol.24 (10), p.5420-5427
Main Authors: Yang, Liping, Liu, Baoer, Chen, Haodong, Gao, Rui, Huang, Kanghua, Guo, Qiuyi, Li, Feng, Chen, Weicai, He, Jinsong
Format: Article
Language:English
Subjects:
Animal models
Bioengineering
Biology
Blood & organ donations
Breast cancer
Cancer research
Cancer therapies
Cell culture
Drug development
Drug resistance
Lymphocytes
Medical research
Metastases
Metastasis
organoid
Organoids
Patients
Review
Reviews
Signal transduction
Stem cells
studying model
Tumors
Womens health
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Summary:Breast cancer is the most common cancer diagnosed in women. Breast cancer research is currently based mainly on animal models and traditional cell culture. However, the inherent species gap between humans and animals, as well as differences in organization between organs and cells, limits research advances. The breast cancer organoid can reproduce many of the key features of human breast cancer, thereby providing a new platform for investigating the mechanisms underlying the development, progression, metastasis and drug resistance of breast cancer. The application of organoid technology can also promote drug discovery and the design of individualized treatment strategies. Here, we discuss the latest advances in the use of organoid technology for breast cancer research.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15216