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Nutrition and Genetics in NAFLD: The Perfect Binomium
Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH),...
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| Published in: | International journal of molecular sciences 2020-04, Vol.21 (8), p.2986 |
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| container_title | International journal of molecular sciences |
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| creator | Meroni, Marica Longo, Miriam Rustichelli, Alice Dongiovanni, Paola |
| description | Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as
which encompasses both
and
It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management. |
| doi_str_mv | 10.3390/ijms21082986 |
| format | article |
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which encompasses both
and
It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21082986</identifier><identifier>PMID: 32340286</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Biomarkers ; Cirrhosis ; Deoxyribonucleic acid ; Diabetes mellitus (non-insulin dependent) ; Diet ; Disease ; Disease Susceptibility ; DNA ; DNA methylation ; Energy Metabolism ; Enzymes ; Epidemiology ; Epigenetics ; Ethnicity ; Evolution & development ; Fatty acids ; Fatty liver ; Fibrosis ; Gene expression ; Genetic Predisposition to Disease ; Genetic Variation ; Genomes ; Genomics ; Hepatocellular carcinoma ; Humans ; Intestinal microflora ; Intestine ; Liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Medical research ; Metabolic disorders ; Metabolic syndrome ; Metabolites ; Microbiota ; Mutation ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - pathology ; Nutrients ; Nutrigenomics - methods ; Nutrition ; Nutrition research ; Nutritional Status ; Pathogenesis ; Pathophysiology ; Physical activity ; Public health ; Review ; Risk analysis ; Risk Factors ; Steatosis ; Studies ; Vitamin B ; Weight control</subject><ispartof>International journal of molecular sciences, 2020-04, Vol.21 (8), p.2986</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-7d489fd02eb0b644f77e8a9c9b1072fc5cfdf18a3cf35c00563fc27ebf6efeb63</citedby><cites>FETCH-LOGICAL-c412t-7d489fd02eb0b644f77e8a9c9b1072fc5cfdf18a3cf35c00563fc27ebf6efeb63</cites><orcidid>0000-0002-4161-4178 ; 0000-0003-4343-7213</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2395422098/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2395422098?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32340286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meroni, Marica</creatorcontrib><creatorcontrib>Longo, Miriam</creatorcontrib><creatorcontrib>Rustichelli, Alice</creatorcontrib><creatorcontrib>Dongiovanni, Paola</creatorcontrib><title>Nutrition and Genetics in NAFLD: The Perfect Binomium</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as
which encompasses both
and
It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Cirrhosis</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diet</subject><subject>Disease</subject><subject>Disease Susceptibility</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Energy Metabolism</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Ethnicity</subject><subject>Evolution & development</subject><subject>Fatty acids</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Gene expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Medical research</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Mutation</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>Non-alcoholic Fatty Liver Disease - metabolism</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>Nutrients</subject><subject>Nutrigenomics - methods</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Nutritional Status</subject><subject>Pathogenesis</subject><subject>Pathophysiology</subject><subject>Physical activity</subject><subject>Public health</subject><subject>Review</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Steatosis</subject><subject>Studies</subject><subject>Vitamin B</subject><subject>Weight control</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkMFLwzAUh4Mobk5vnqXg1epL0rSJB2FON4UxPcxzaNPEZazpTFrB_96OzTFP78H7-L0fH0KXGG4pFXBnl1UgGDgRPD1CfZwQEgOk2fHB3kNnISwBCCVMnKIeJTQBwtM-YrO28baxtYtyV0YT7XRjVYisi2bD8fTpPpovdPSuvdGqiR6tqyvbVufoxOSroC92c4A-xs_z0Us8fZu8jobTWCWYNHFWJlyYEoguoEiTxGSZ5rlQosCQEaOYMqXBPKfKUKYAWEqNIpkuTKqNLlI6QA_b3HVbVLpU2jU-X8m1t1Xuf2SdW_n_4uxCftbfMiOYcca7gOtdgK-_Wh0auaxb77rOklDBOj8gNtTNllK-DsFrs_-AQW4ky0PJHX512GoP_1mlvxLveBY</recordid><startdate>20200423</startdate><enddate>20200423</enddate><creator>Meroni, Marica</creator><creator>Longo, Miriam</creator><creator>Rustichelli, Alice</creator><creator>Dongiovanni, Paola</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4161-4178</orcidid><orcidid>https://orcid.org/0000-0003-4343-7213</orcidid></search><sort><creationdate>20200423</creationdate><title>Nutrition and Genetics in NAFLD: The Perfect Binomium</title><author>Meroni, Marica ; Longo, Miriam ; Rustichelli, Alice ; Dongiovanni, Paola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-7d489fd02eb0b644f77e8a9c9b1072fc5cfdf18a3cf35c00563fc27ebf6efeb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Cirrhosis</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diet</topic><topic>Disease</topic><topic>Disease Susceptibility</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Energy Metabolism</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Epigenetics</topic><topic>Ethnicity</topic><topic>Evolution & development</topic><topic>Fatty acids</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Gene expression</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Medical research</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Mutation</topic><topic>Non-alcoholic Fatty Liver Disease - etiology</topic><topic>Non-alcoholic Fatty Liver Disease - metabolism</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>Nutrients</topic><topic>Nutrigenomics - methods</topic><topic>Nutrition</topic><topic>Nutrition research</topic><topic>Nutritional Status</topic><topic>Pathogenesis</topic><topic>Pathophysiology</topic><topic>Physical activity</topic><topic>Public health</topic><topic>Review</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Steatosis</topic><topic>Studies</topic><topic>Vitamin B</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meroni, Marica</creatorcontrib><creatorcontrib>Longo, Miriam</creatorcontrib><creatorcontrib>Rustichelli, Alice</creatorcontrib><creatorcontrib>Dongiovanni, Paola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meroni, Marica</au><au>Longo, Miriam</au><au>Rustichelli, Alice</au><au>Dongiovanni, Paola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutrition and Genetics in NAFLD: The Perfect Binomium</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-04-23</date><risdate>2020</risdate><volume>21</volume><issue>8</issue><spage>2986</spage><pages>2986-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as
which encompasses both
and
It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32340286</pmid><doi>10.3390/ijms21082986</doi><orcidid>https://orcid.org/0000-0002-4161-4178</orcidid><orcidid>https://orcid.org/0000-0003-4343-7213</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomarkers Cirrhosis Deoxyribonucleic acid Diabetes mellitus (non-insulin dependent) Diet Disease Disease Susceptibility DNA DNA methylation Energy Metabolism Enzymes Epidemiology Epigenetics Ethnicity Evolution & development Fatty acids Fatty liver Fibrosis Gene expression Genetic Predisposition to Disease Genetic Variation Genomes Genomics Hepatocellular carcinoma Humans Intestinal microflora Intestine Liver Liver cancer Liver cirrhosis Liver diseases Medical research Metabolic disorders Metabolic syndrome Metabolites Microbiota Mutation Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Nutrients Nutrigenomics - methods Nutrition Nutrition research Nutritional Status Pathogenesis Pathophysiology Physical activity Public health Review Risk analysis Risk Factors Steatosis Studies Vitamin B Weight control |
| title | Nutrition and Genetics in NAFLD: The Perfect Binomium |
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