LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty live...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-04, Vol.21 (8), p.2883
Main Authors: Kim, Young-Ah, Park, Kwan-Kyu, Lee, Sun-Jae
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological activity
Biomarkers
Biomarkers, Tumor
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell cycle
Cell growth
Chemical Phenomena
Cirrhosis
Diagnostic systems
Disease Progression
Disease Susceptibility
DNA methylation
Epigenetics
Fatty liver
Fibrosis
Genes
Hepatitis
Hepatocellular carcinoma
Humans
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Liver Diseases - complications
Liver Diseases - virology
Liver Neoplasms - etiology
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Medical prognosis
Metabolism
Metastasis
MicroRNAs
Molecular modelling
Non-coding RNA
Pathogenesis
Pathophysiology
Proteins
Review
RNA, Long Noncoding
Roles
Therapeutic applications
Tumorigenesis
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Description
Summary:Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and viral hepatitis, has only recently been considered in scientific research. While extensive studies on the pathogenesis of the development of HCC from hepatic fibrosis have been conducted, their regulatory molecular mechanisms are still only partially understood. The underlying mechanisms related to lncRNAs leading to HCC from chronic liver diseases and cirrhosis have not yet been entirely elucidated. Therefore, elucidating the functional roles of lncRNAs in chronic liver disease and HCC can contribute to a better understanding of the molecular mechanisms, and may help in developing novel diagnostic biomarkers and therapeutic targets for HCC, as well as in preventing the progression of chronic liver disease to HCC. Here, we comprehensively review and briefly summarize some lncRNAs that participate in both hepatic fibrosis and HCC.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21082883