Cytokine‐induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche

Peripheral blood hematopoietic stem and progenitor cells (HSPCs), mobilized by granulocyte colony‐stimulating factor, are widely used as a source for both autologous and allogeneic stem cell transplantation. The use of mobilized HSPCs has several advantages over traditional bone marrow–derived HSPCs...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2020-04, Vol.1466 (1), p.24-38
Main Authors: Kruijf, Evert‐Jan F.M., Fibbe, Willem E., Pel, Melissa
Format: Article
Language:English
Subjects:
Autografts
Bone marrow
Cytokines
G‐CSF
Hematopoietic stem cells
Immunology
Leukocytes (granulocytic)
Molecular Biology
Peripheral blood
Physiology
Progenitor cells
Review
Reviews
stem cell mobilization
stem cell niche
Stem cell transplantation
Stem cells
Transplantation
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Summary:Peripheral blood hematopoietic stem and progenitor cells (HSPCs), mobilized by granulocyte colony‐stimulating factor, are widely used as a source for both autologous and allogeneic stem cell transplantation. The use of mobilized HSPCs has several advantages over traditional bone marrow–derived HSPCs, including a less invasive harvesting process for the donor, higher HSPC yields, and faster hematopoietic reconstitution in the recipient. For years, the mechanisms by which cytokines and other agents mobilize HSPCs from the bone marrow were not fully understood. The field of stem cell mobilization research has advanced significantly over the past decade, with major breakthroughs in the elucidation of the complex mechanisms that underlie stem cell mobilization. In this review, we provide an overview of the events that underlie HSPC mobilization and address the relevant cellular and molecular components of the bone marrow niche. Furthermore, current and future mobilizing agents will be discussed. Hematopoietic stem and progenitor cells (HSPCs) mobilized from the bone marrow to the peripheral blood by granulocyte colony‐stimulating factor (G‐CSF) are widely used for stem cell transplantation and have advantages over traditional bone marrow–derived HSPCs. This review provides an overview of the events that underlie HSPC mobilization and addresses the relevant cellular and molecular components of the bone marrow niche from which the HPSCs are mobilized from.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.14059