Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility

This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized...

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Bibliographic Details
Published in:Scientific reports 2020-05, Vol.10 (1), p.7859-7859, Article 7859
Main Authors: Liu, Dan, Pan, Jian-Min, Pei, Xiang, Li, Jun-Sen
Format: Article
Language:English
Subjects:
45/41
631/208/205
692/699/2743/137
Aged
Alleles
Apolipoproteins
Apolipoproteins M - genetics
Apolipoproteins M - metabolism
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - genetics
Female
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes
Humanities and Social Sciences
Humans
M gene
Male
Mathematical models
Middle Aged
multidisciplinary
Obesity
Obesity - diagnosis
Obesity - genetics
Polymorphism, Single Nucleotide
Protein Binding
Risk Factors
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Summary:This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed in silico using the haplotype analysis algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 (1.10–1.66) ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-64467-6