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Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility
This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized...
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| Published in: | Scientific reports 2020-05, Vol.10 (1), p.7859-7859, Article 7859 |
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| description | This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed
in silico
using the haplotype analysis algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 (1.10–1.66) (
p
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| doi_str_mv | 10.1038/s41598-020-64467-6 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7217861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2401741951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-70f927533bfc34ed1a74e780332b7a82ed1cd771f08670e36dc907d6aa540653</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiNERau2L8ACWWLDJuBb4mSDVEpbKrUUqWdvOc7k1JVjB9sB5Sl45fr0lF5Y4I1nPN_8ntFfFG8J_kgwaz5FTqq2KTHFZc15Lcr6VbFHMa9Kyih9_SzeLQ5jvMX5VLTlpH1T7DLK2kaQaq_4c-4SBKWT8Q59gfQbwKGjyVsz-Sn4BMahS3QGDtC1cWsL5fdZW_DJ9IB-eLuMPkw3Jo4RKdejqw6iSct9bFJEJ8MAOqGsvVomQBR9NaqDBBFdgrUmzRFdz1HDlExncr4cFDuDshEOH-79YnV6sjr-Vl5cnZ0fH12UuqI0lQIPLRUVY92gGYeeKMFBNJgx2gnV0PyieyHIgJtaYGB1r1ss-lqpiuO6YvvF563sNHcj9BpcCsrKKZhRhUV6ZeTLijM3cu1_SUGJaGqSBT48CAT_c4aY5GjyHtYqB36OknJMOcsjNhl9_w966-fg8nYbiohsSbURpFtKBx9jgOFxGILlxnG5dVxmx-W947LOTe-er_HY8tffDLAtEHPJrSE8_f0f2TvJ4LjF</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2401741951</pqid></control><display><type>article</type><title>Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Liu, Dan ; Pan, Jian-Min ; Pei, Xiang ; Li, Jun-Sen</creator><creatorcontrib>Liu, Dan ; Pan, Jian-Min ; Pei, Xiang ; Li, Jun-Sen</creatorcontrib><description>This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed
in silico
using the haplotype analysis algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 (1.10–1.66) (
p
< 0.001). Moreover, the individuals with 724-delallele have a higher risk of T2DM compared to those with 724-ins variants, adjusted OR (95%CI) = 1.66 (1.40–2.06),
p
< 0.001. GMDR analysis suggested that the interaction model composed of the two factors, rs805296 and obesity, was the best model with statistical significance (P value from sign test [
P
sign
]=0.0107). The T2DM risk in obese individuals having TC or CC genotype was higher than non-obese individuals with TT genotype (OR = 2.38, 95% CI = 1.58–3.53). Haplotype analysis suggests that rs805297-C and rs9404941-C alleles haplotype indicate high risk of T2DM, OR (95%CI) = 1.62 (1.29–2.16),
p
< 0.001. Our results suggested that rs805296 and 724-del minor allele of ApoM gene, interaction of rs805296 and obesity, rs805297-C and rs9404941-C alleles haplotype were indicators of high T2DM risk.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-64467-6</identifier><identifier>PMID: 32398715</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/41 ; 631/208/205 ; 692/699/2743/137 ; Aged ; Alleles ; Apolipoproteins ; Apolipoproteins M - genetics ; Apolipoproteins M - metabolism ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - genetics ; Female ; Gene Frequency ; Gene polymorphism ; Genetic Predisposition to Disease - genetics ; Genotype ; Haplotypes ; Humanities and Social Sciences ; Humans ; M gene ; Male ; Mathematical models ; Middle Aged ; multidisciplinary ; Obesity ; Obesity - diagnosis ; Obesity - genetics ; Polymorphism, Single Nucleotide ; Protein Binding ; Risk Factors ; Science ; Science (multidisciplinary) ; Single-nucleotide polymorphism</subject><ispartof>Scientific reports, 2020-05, Vol.10 (1), p.7859-7859, Article 7859</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-70f927533bfc34ed1a74e780332b7a82ed1cd771f08670e36dc907d6aa540653</citedby><cites>FETCH-LOGICAL-c522t-70f927533bfc34ed1a74e780332b7a82ed1cd771f08670e36dc907d6aa540653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2401741951/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2401741951?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32398715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Pan, Jian-Min</creatorcontrib><creatorcontrib>Pei, Xiang</creatorcontrib><creatorcontrib>Li, Jun-Sen</creatorcontrib><title>Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed
in silico
using the haplotype analysis algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 (1.10–1.66) (
p
< 0.001). Moreover, the individuals with 724-delallele have a higher risk of T2DM compared to those with 724-ins variants, adjusted OR (95%CI) = 1.66 (1.40–2.06),
p
< 0.001. GMDR analysis suggested that the interaction model composed of the two factors, rs805296 and obesity, was the best model with statistical significance (P value from sign test [
P
sign
]=0.0107). The T2DM risk in obese individuals having TC or CC genotype was higher than non-obese individuals with TT genotype (OR = 2.38, 95% CI = 1.58–3.53). Haplotype analysis suggests that rs805297-C and rs9404941-C alleles haplotype indicate high risk of T2DM, OR (95%CI) = 1.62 (1.29–2.16),
p
< 0.001. Our results suggested that rs805296 and 724-del minor allele of ApoM gene, interaction of rs805296 and obesity, rs805297-C and rs9404941-C alleles haplotype were indicators of high T2DM risk.</description><subject>45/41</subject><subject>631/208/205</subject><subject>692/699/2743/137</subject><subject>Aged</subject><subject>Alleles</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins M - genetics</subject><subject>Apolipoproteins M - metabolism</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>M gene</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Obesity</subject><subject>Obesity - diagnosis</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Protein Binding</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kctu1TAQhiNERau2L8ACWWLDJuBb4mSDVEpbKrUUqWdvOc7k1JVjB9sB5Sl45fr0lF5Y4I1nPN_8ntFfFG8J_kgwaz5FTqq2KTHFZc15Lcr6VbFHMa9Kyih9_SzeLQ5jvMX5VLTlpH1T7DLK2kaQaq_4c-4SBKWT8Q59gfQbwKGjyVsz-Sn4BMahS3QGDtC1cWsL5fdZW_DJ9IB-eLuMPkw3Jo4RKdejqw6iSct9bFJEJ8MAOqGsvVomQBR9NaqDBBFdgrUmzRFdz1HDlExncr4cFDuDshEOH-79YnV6sjr-Vl5cnZ0fH12UuqI0lQIPLRUVY92gGYeeKMFBNJgx2gnV0PyieyHIgJtaYGB1r1ss-lqpiuO6YvvF563sNHcj9BpcCsrKKZhRhUV6ZeTLijM3cu1_SUGJaGqSBT48CAT_c4aY5GjyHtYqB36OknJMOcsjNhl9_w966-fg8nYbiohsSbURpFtKBx9jgOFxGILlxnG5dVxmx-W947LOTe-er_HY8tffDLAtEHPJrSE8_f0f2TvJ4LjF</recordid><startdate>20200512</startdate><enddate>20200512</enddate><creator>Liu, Dan</creator><creator>Pan, Jian-Min</creator><creator>Pei, Xiang</creator><creator>Li, Jun-Sen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200512</creationdate><title>Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility</title><author>Liu, Dan ; Pan, Jian-Min ; Pei, Xiang ; Li, Jun-Sen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-70f927533bfc34ed1a74e780332b7a82ed1cd771f08670e36dc907d6aa540653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>45/41</topic><topic>631/208/205</topic><topic>692/699/2743/137</topic><topic>Aged</topic><topic>Alleles</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins M - genetics</topic><topic>Apolipoproteins M - metabolism</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>M gene</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Obesity</topic><topic>Obesity - diagnosis</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Protein Binding</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Pan, Jian-Min</creatorcontrib><creatorcontrib>Pei, Xiang</creatorcontrib><creatorcontrib>Li, Jun-Sen</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Dan</au><au>Pan, Jian-Min</au><au>Pei, Xiang</au><au>Li, Jun-Sen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-05-12</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>7859</spage><epage>7859</epage><pages>7859-7859</pages><artnum>7859</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study investigated the correlation of four single nucleotide polymorphisms (SNPs) in Apolipoprotein M (ApoM) with the risk of type 2 diabetes mellitus (T2DM) and effects of the interactions of this gene and obesity. The effects of SNP and obesity interaction on T2DM was examined by generalized multifactor dimensionality reduction (GMDR) combined with the logistic regression model. T2DM patient-control haplotype was analyzed
in silico
using the haplotype analysis algorithm SHEsis. The rs805296-C allele or 724-del allele indicted high risk of T2DM. The incidence of T2DM in individuals with rs805296-C allele polymorphism (TC + CC) was higher than those without (TT), adjusted OR (95%CI) = 1.29 (1.10–1.66) (
p
< 0.001). Moreover, the individuals with 724-delallele have a higher risk of T2DM compared to those with 724-ins variants, adjusted OR (95%CI) = 1.66 (1.40–2.06),
p
< 0.001. GMDR analysis suggested that the interaction model composed of the two factors, rs805296 and obesity, was the best model with statistical significance (P value from sign test [
P
sign
]=0.0107). The T2DM risk in obese individuals having TC or CC genotype was higher than non-obese individuals with TT genotype (OR = 2.38, 95% CI = 1.58–3.53). Haplotype analysis suggests that rs805297-C and rs9404941-C alleles haplotype indicate high risk of T2DM, OR (95%CI) = 1.62 (1.29–2.16),
p
< 0.001. Our results suggested that rs805296 and 724-del minor allele of ApoM gene, interaction of rs805296 and obesity, rs805297-C and rs9404941-C alleles haplotype were indicators of high T2DM risk.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32398715</pmid><doi>10.1038/s41598-020-64467-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45/41 631/208/205 692/699/2743/137 Aged Alleles Apolipoproteins Apolipoproteins M - genetics Apolipoproteins M - metabolism Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - genetics Female Gene Frequency Gene polymorphism Genetic Predisposition to Disease - genetics Genotype Haplotypes Humanities and Social Sciences Humans M gene Male Mathematical models Middle Aged multidisciplinary Obesity Obesity - diagnosis Obesity - genetics Polymorphism, Single Nucleotide Protein Binding Risk Factors Science Science (multidisciplinary) Single-nucleotide polymorphism |
| title | Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility |
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