Increasing incidence and improving survival of oral tongue squamous cell carcinoma

• Published in: Scientific reports 2020-05, Vol.10 (1), p.7877-7877, Article 7877
• Main Authors: Kim, Yi-Jun, Kim, Jin Ho
• Format: Article
• Language: English
• Subjects: 692/4028/67/1536/1665; 692/4028/67/2324; Adenomatous polyposis coli; Aged; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Conditioned stimulus; Epidemiology; Female; Head & neck cancer; Humanities and Social Sciences; Humans; Incidence; Male; Medical prognosis; Middle Aged; Mouth Neoplasms - epidemiology; Mouth Neoplasms - pathology; Mouth Neoplasms - therapy; multidisciplinary; Multivariate Analysis; Oral cancer; Papillomavirus Infections - epidemiology; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Prognosis; Science; Science (multidisciplinary); SEER Program - statistics & numerical data; SEER Program - trends; Squamous cell carcinoma; Survival; Survival Analysis; Tongue; Tongue Neoplasms - epidemiology; Tongue Neoplasms - pathology; Tongue Neoplasms - therapy; United States - epidemiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-64748-0

We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database. Five anatomical sites and their subsites were analyzed. Annual percent change (APC) of incidence was calculated. RS and CS were compared across the four decades. Adjusted hazard ratios (aHRs) of RS were evaluated using multivariate regression. OTSCC incidence decreased from 1976 (APC = −0.76, P