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A Pilot Study Comparing Aortic Valve Area Estimates Derived from Fick Cardiac Output with Estimates Based on Cheetah-NICOM Cardiac Output
Cardiac output during cardiac catheterization is often estimated using the modified Fick method (CO Fick ). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing CO Fick in the Gorlin formula with Cheetah-NICOM mo...
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Published in: | Scientific reports 2020-05, Vol.10 (1), p.7852-7852, Article 7852 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Cardiac output during cardiac catheterization is often estimated using the modified Fick method (CO
Fick
). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing CO
Fick
in the Gorlin formula with Cheetah-NICOM monitor cardiac output (CO
Cheetah
) could produce an accurate and precise estimate of aortic valve area in patients with severe aortic stenosis. In twenty-six subjects, CO
Fick
and CO
Cheetah
were obtained concurrently. A spot and 3-minute running average of CO
Cheetah
was used. Bland and Altman analysis was used to derive bias, 95% limits of agreement (LOA) and confidence intervals (CI). The mean difference (bias) between AVA
Cheetah
(average) and AVA
Fick
was 0.11 cm
2
and the 95% LOA were ±0.42 cm
2
. The 95% CI of the bias was 0.02–0.2 cm
2
. The bias and 95% LOA of AVA
Cheetah
(spot value) were 0.14 ± 0.42cm
2
, with a 95% CI of 0.06–0.23 cm
2
. No proportional bias was present. AVA
Cheetah
thus appears to be a reasonably accurate measure of AVA in patients with severe aortic stenosis compared to AVA
Fick
measured using a modified Fick CO. However, the limits of agreement were not narrow enough to consider AVA
Cheetah
and AVA
Fick
interchangeable. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-020-64753-3 |