A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs

• Published in: Journal of Toxicologic Pathology 2020, Vol.33(2), pp.105-113
• Main Authors: Saito, Tsubasa, Nibe, Kazumi, Chambers, James K., Uneyama, Mizuho, Nakashima, Ko, Ohno, Koichi, Tsujimoto, Hajime, Uchida, Kazuyuki, Nakayama, Hiroyuki
• Format: Article
• Language: English
• Subjects: Biopsy; Carcinoma; dog; Dogs; Gastric cancer; gastric tumor; Growth patterns; histopathology; intestinal tumor; Intestine; Metastases; Metastasis; Original; spontaneous epithelial tumor; Tumors
• ISSN: 0914-9198; 1881-915X; 1347-7404
• DOI: 10.1293/tox.2019-0076

The present study evaluated the histopathological features, biological nature, anatomical location, sex, age and breeds of dogs affected by spontaneous gastrointestinal epithelial tumor. Biopsy samples of gastrointestinal tumors, from 95 dogs were examined and classified according to the WHO histological classification. A total of 131 samples, including 38 gastric, 13 small intestinal, and 80 large intestinal tumors were examined. The study observed that Jack Russell Terriers and Miniature Dachshunds were the breeds with the highest predisposition for gastrointestinal tumors. Gastric tumors included 5 adenomas, 30 adenocarcinomas (12 tubular, 2 papillary, 4 tubulopapillary and 12 signet-ring cell carcinomas) and 3 undifferentiated carcinomas. Intestinal tumors included 35 adenomas, 57 adenocarcinomas (43 acinar, 4 papillary, 7 mucinous and 3 signet-ring cell carcinomas), and 1 undifferentiated carcinoma. The study did not detect any difference among the incidence rates of invasion/metastasis in the tubular (44%), papillary (33%) and tubulopapillary (25%) adenocarcinomas. Additionally, the tubular (acinar), papillary and tubulopapillary adenocarcinomas were further divided into 48 polypoid and 17 non-polypoid types, based on their growth patterns. Invasion/metastasis was detected in 21% of the polypoid type and 100% of the non-polypoid type of adenocarcinomas. A correlation was detected between the occurrence of invasion/metastasis and the type of histopathological growth pattern in adenocarcinomas. The study demonstrated that Jack Russell terriers and Miniature Dachshunds are the most common breeds affected by gastrointestinal tumors and the entire group of the canine adenocarcinomas with non-polypoid growth pattern has greater malignant potentials, compared to the adenocarcinomas with polypoid growth patterns.