Modular Approach to the Functionalization of Polymersomes

Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly. Her...

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Bibliographic Details
Published in:Biomacromolecules 2020-05, Vol.21 (5), p.1853-1864
Main Authors: Rijpkema, Sjoerd J, Langens, Sabine G. H. A, van der Kolk, Marnix R, Gavriel, Katerina, Toebes, B. Jelle, Wilson, Daniela A
Format: Article
Language:English
Subjects:
Polymers
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Summary:Functionalizing polymersomes remains a challenge due to the limitation in reaction conditions applicable to the chemistry on the surface, hindering their application for selective targeting. In order to overcome this limitation, functionalization can be introduced right before the self-assembly. Here, we have synthesized a library (32 examples) of PEG-b-PS and PEG-b-PDLLA with various functional groups derived from the amine-functionalized polymers, leading to functionally active polymersomes. We show that polymersome formation is possible via the general method with all functionalized groups and that these handles are present on the surface and are able to undergo reactions. Additionally, this methodology provides a general synthetic tool to tailor the functional group of the polymersome right before self-assembly, without limitation on the reaction conditions.
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.9b01734