Hypoglycemia with insulin and sulfonylureas

The incidence of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) taking insulin alone, sulfonylurea (SU) alone, or the combination of insulin and SU is low (strength of recommendation (SOR) A based on a systematic review of randomized controlled trials). The combination of insul...

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Bibliographic Details
Published in:Canadian family physician 2020-05, Vol.66 (5), p.335-335
Main Authors: Kolman, Karyn B, Freeman, Joshua, Howe, Carol L
Format: Article
Language:English
Subjects:
Clinical trials
Diabetes
Family physicians
Health risk assessment
Hypoglycemia
Insulin
Practice
Online Access:Get full text
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Summary:The incidence of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) taking insulin alone, sulfonylurea (SU) alone, or the combination of insulin and SU is low (strength of recommendation (SOR) A based on a systematic review of randomized controlled trials). The combination of insulin and SU in patients with T2DM does increase the risk of hypoglycemia; however, the clinical significance of this risk is small (SOR B based on 4 large retrospective cohort studies). Of note, patients 65 years and older are at an increased risk of hypoglycemia compared with younger patients, although the clinical significance has not been specified (SOR B based on 2 large retrospective cohort studies).
ISSN:0008-350X
1715-5258