Low-grade albuminuria is associated with hearing loss in non-diabetic US males: A cross-sectional analysis of 1999-2004 national health and nutrition examination survey

High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (U...

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Bibliographic Details
Published in:Medicine (Baltimore) 2020-03, Vol.99 (11), p.e19284-e19284
Main Authors: Wang, Tang-Chuan, Chang, Ta-Yuan, Salvi, Richard, Juan, Chun-Jung, Liu, Yi-Wen, Chang, Chia-Hao, Chiu, Chien-Jen, Lin, Chia-Der, Tsai, Ming-Hsui
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Albuminuria - complications
Albuminuria - diagnosis
Audiometry - methods
Blood Glucose - analysis
Comorbidity
Cross-Sectional Studies
Diabetes Mellitus
Glomerular Filtration Rate
Hearing Loss - diagnosis
Hearing Loss - epidemiology
Hearing Loss - etiology
Humans
Incidence
Linear Models
Male
Middle Aged
Multivariate Analysis
Nutrition Surveys
Observational Study
Reference Values
Risk Assessment
Severity of Illness Index
United States
Urinalysis - methods
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Summary:High levels of albuminuria have been demonstrated to associate with hearing loss in non-diabetic people, while the clinical impact of low-grade albuminuria has attracted less attention. This cross-sectional population-based study aimed to examine whether hearing loss in non-diabetic United States (US) adults is independently associated with low-grade albuminuria or reduced estimated glomeruli filtration rate (eGFR).A total of 2518 participants aged 20 to 69 years were selected from the US National Health and Nutritional Examination Survey database. Participants with diabetes or high-grade albuminuria were excluded. Hearing loss was assessed using low-frequency pure-tone average (LFPTA) thresholds (0.5, 1.0, 2.0 kHz) and high-frequency pure-tone average (HFPTA) thresholds (3.0, 4.0, 6.0, 8.0 kHz). Logistic and linear regression analyses were used to evaluate associations between renal function indicators and hearing loss.The median age of included participants was 37.4 years, and 55% of them were female. Multivariate analysis revealed that participants with urinary albumin-to-creatinine ratio (UACR) in the highest tertile had a significantly higher risk of hearing loss (OR, 1.79; 95% CI, 1.01-3.19) and higher HFPTA thresholds (β: 2.23; SE: 0.77). Participants with eGFR
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000019284