Bacterial biopolymers: from pathogenesis to advanced materials

• Published in: Nature reviews. Microbiology 2020-04, Vol.18 (4), p.195-210
• Main Authors: Moradali, M. Fata, Rehm, Bernd H. A.
• Format: Article
• Language: English
• Subjects: 631/326/252/318; 631/326/2522; 631/326/41/2173; 631/326/41/2531; 639/301/923/1028; Bacteria; Bacteria - metabolism; Bacteria - pathogenicity; Bacterial physiology; Bacteriology, Medical; Biological materials; Biomaterials; Biomedical and Life Sciences; Biomedical materials; Biopolymers; Biopolymers - metabolism; Carbon sources; Chemical synthesis; Deoxyribonucleic acid; DNA; Drug development; Factories; Industrial applications; Infectious Diseases; Interdisciplinary research; Interdisciplinary studies; Life Sciences; Material properties; Medical materials; Medical Microbiology; Microbiological research; Microbiological synthesis; Microbiology; Molecular modelling; Nitrogen sources; Nylons - metabolism; Parasitology; Pathogenesis; Pathogenicity; Pathogens; Plant layout; Polyamide resins; Polyamides; Polyester resins; Polyesters; Polyesters - metabolism; Polymers; Polyphosphates; Polyphosphates - metabolism; Polysaccharides; Polysaccharides, Bacterial - metabolism; Production processes; Properties; Review; Review Article; Saccharides; Target recognition; Virology; Virulence; Virulence factors
• ISSN: 1740-1526; 1740-1534
• DOI: 10.1038/s41579-019-0313-3

Bacteria are prime cell factories that can efficiently convert carbon and nitrogen sources into a large diversity of intracellular and extracellular biopolymers, such as polysaccharides, polyamides, polyesters, polyphosphates, extracellular DNA and proteinaceous components. Bacterial polymers have important roles in pathogenicity, and their varied chemical and material properties make them suitable for medical and industrial applications. The same biopolymers when produced by pathogenic bacteria function as major virulence factors, whereas when they are produced by non-pathogenic bacteria, they become food ingredients or biomaterials. Interdisciplinary research has shed light on the molecular mechanisms of bacterial polymer synthesis, identified new targets for antibacterial drugs and informed synthetic biology approaches to design and manufacture innovative materials. This Review summarizes the role of bacterial polymers in pathogenesis, their synthesis and their material properties as well as approaches to design cell factories for production of tailor-made bio-based materials suitable for high-value applications. Bacteria produce diverse polymers, such as polysaccharides, polyesters, polyphosphates and extracellular DNA. In this Review, Moradali and Rehm discuss the types of bacterial polymers and their role in bacterial physiology and pathogenesis as well as their production and use as novel biomaterials.