Diagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer

The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant sh...

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Bibliographic Details
Published in:Cancer science 2020-05, Vol.111 (5), p.1856-1861
Main Authors: Koi, Yumiko, Tsutani, Yasuhiro, Nishiyama, Yukie, Kanda, Miyuki, Shiroma, Yoshitomo, Yamamoto, Yuki, Sasada, Shinsuke, Akita, Tomoyuki, Masumoto, Norio, Kadoya, Takayuki, Takahashi, Ryou‐u, Tanaka, Junko, Okada, Morihito, Tahara, Hidetoshi
Format: Article
Language:English
Subjects:
Age
biomarker
Biomarkers
Breast cancer
Case Report
Chromosomes
Deoxyribonucleic acid
DNA
Epidermal growth factor
Estrogens
leukocyte
Mammography
Studies
Tails
telomere
telomere G‐tail
Telomeres
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Summary:The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G‐tail length might be a potential biomarker for BC detection. Telomere G‐tail length correlates with the presence of breast cancer.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14378