Composite Hydrogel Model of Cartilage Predicts Its Load-Bearing Ability

Articular cartilage is a load-bearing tissue found in animal and human joints. It is a composite gel-like material in which a fibrous collagen network encapsulates large proteoglycan assemblies that imbibe fluid and “inflate” the network. Here we describe a composite hydrogel consisting of a cross-l...

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Bibliographic Details
Published in:Scientific reports 2020-05, Vol.10 (1), p.8103-8103, Article 8103
Main Authors: Horkay, Ferenc, Basser, Peter J.
Format: Article
Language:English
Subjects:
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Acrylic acid
Aged
Arthritis
Biocompatible Materials - chemistry
Biomechanics
Biomimetics
Cartilage
Cartilage (articular)
Cartilage, Articular - physiology
Case-Control Studies
Chondrocytes - physiology
Collagen
Composite materials
Degeneration
Equilibrium
Extracellular Matrix
Humanities and Social Sciences
Humans
Hydrogels
Hydrogels - chemistry
Investigations
Load
Materials Testing
Mechanical properties
Microparticles
Middle Aged
multidisciplinary
Osteoarthritis
Osteoarthritis - physiopathology
Polymers
Polyvinyl alcohol
Proteoglycans
Regenerative medicine
Science
Science (multidisciplinary)
Tissue Engineering
Weight-Bearing
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Summary:Articular cartilage is a load-bearing tissue found in animal and human joints. It is a composite gel-like material in which a fibrous collagen network encapsulates large proteoglycan assemblies that imbibe fluid and “inflate” the network. Here we describe a composite hydrogel consisting of a cross-linked polyvinyl alcohol matrix filled with poly(acrylic acid) microparticles that mimics functional properties and biomechanical behavior of cartilage. The swelling and mechanical behaviors of this biomimetic model system are strikingly similar to that of human cartilage. The development of synthetic composite gel-based articular cartilage analog suggests new avenues to explore material properties, and their change in disease and degeneration, as well as novel strategies for developing composite tissue-engineered cartilage constructs for regenerative medicine applications.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-64917-1