Hybrid (2D/3D) Dosimetry of Radiolabeled Gold Nanoparticles for Sentinel Lymph Node Detection in Patients with Breast Cancer

Previously, we reported the preparation and preclinical studies of 99mTc-labeled gold nanoparticles-mannose (99mTc-AuNP-mannose) with potential for sentinel lymph node (SLN) detection by using nuclear medicine procedures. This study aimed to evaluate the biokinetics and hybrid (2D/3D) dosimetry of 9...

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Bibliographic Details
Published in:Contrast media and molecular imaging 2020, Vol.2020 (2020), p.1-7
Main Authors: García-Perez, Osvaldo, Gómez-Argumosa, Edgar, Chairez, Isaac, Ocampo-García, Blanca, Ferro-Flores, Guillermina, Santos-Cuevas, Clara, Ramírez-Nava, Gerardo, Abundiz-López, Lucero
Format: Article
Language:English
Subjects:
Algorithms
Breast cancer
Circulatory system
Computed tomography
Diagnostic systems
Dosimeters
Dosimetry
Gold
Image acquisition
Image detection
Kidneys
Lymph nodes
Lymphatic system
Mannose
Medical imaging
Methods
Nanoparticles
Nuclear medicine
Nuclear transformations
Patients
Photon emission
Radiation
Residence time distribution
Side effects
Single photon emission computed tomography
Studies
Tomography
Two dimensional bodies
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Summary:Previously, we reported the preparation and preclinical studies of 99mTc-labeled gold nanoparticles-mannose (99mTc-AuNP-mannose) with potential for sentinel lymph node (SLN) detection by using nuclear medicine procedures. This study aimed to evaluate the biokinetics and hybrid (2D/3D) dosimetry of 99mTc-AuNP-mannose in five patients with breast cancer under a sentinel lymph node detection protocol. Anterior and posterior whole-body planar images (2D, at 0.5, 2, 6, and 24 h) and single-photon emission computed tomography (3D at 6.5 h)/computed tomography (SPECT/CT) images were acquired after 99mTc-AuNP-mannose administration (37 MBq). Through a hybrid quantification method, activity in tissues of interest at the different acquisition times was determined and integrated over time to obtain the total nuclear transformations (N), as well as the mean residence time, in each tissue. N values and the OLINDA code were used for estimating the internal radiation absorbed doses. Results demonstrated that 99mTc-AuNP-mannose successfully accumulates and remains up to 24 h in the sentinel lymph node without detectable migration to other lymph nodes and no side effects on patients. Negligible absorption of the radiolabeled nanoparticles into the circulatory system was observed, from which the radio-nanosystem is rapidly eliminated by kidneys. Hybrid (2D/3D) dosimetry evaluations showed equivalent doses to SLN, breast, and kidneys of 172.34, 5.32, and 0.08 mSv/37 MBq, respectively, with an effective dose of 2.05E − 03 mSv/MBq. The mean effective residence time in SLN was 0.92 h. This preliminary study indicates that the use of 99mTc-AuNP-mannose for successful SLN detection in patients is safe, producing an effective dose at the level recommended for diagnostic studies (
ISSN:1555-4309
1555-4317
DOI:10.1155/2020/2728134