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From Psoriasis to Psoriatic Arthritis: Insights from Imaging on the Transition to Psoriatic Arthritis and Implications for Arthritis Prevention
Purpose of Review To describe the recent advances in the field towards the prevention and early recognition of Psoriatic Arthritis (PsA). Recent Findings Defining the preclinical phase of PsA remains challenging since up to 50% of subjects with psoriasis have subclinical imaging enthesopathy, but ma...
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Published in: | Current rheumatology reports 2020-05, Vol.22 (6), p.24-24, Article 24 |
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creator | Zabotti, Alen Tinazzi, Ilaria Aydin, Sibel Zehra McGonagle, Dennis |
description | Purpose of Review
To describe the recent advances in the field towards the prevention and early recognition of Psoriatic Arthritis (PsA).
Recent Findings
Defining the preclinical phase of PsA remains challenging since up to 50% of subjects with psoriasis have subclinical imaging enthesopathy, but many of these do not progress to PsA. Nevertheless, there is evidence that subjects with subclinical imaging enthesopathy are at increased risk of developing PsA. In recent years, it has been shown that both PsA and anti-citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA) are characterized by a subclinical phase of non-specific or brief duration arthralgia with shared imaging features accounting for joint symptomatology. Sonographically determined tenosynovitis and enthesitis are the key imaging features present in non-specific PsO arthralgia that are at risk of future PsA development. Furthermore, the early phases of PsA are complicated by factors including body mass index (BMI), which is a risk factor for PsA, but BMI is also associated with imaging abnormalities on enthesopathy. Fully disentangling these clinical and imaging factors will be important for enrichment for imminent PsA so that disease prevention strategies can be investigated.
Summary
Psoriasis patients with arthralgia have a higher prevalence of tenosynovitis and imaging enthesopathy is at higher risk of transitioning to overt PsA. |
doi_str_mv | 10.1007/s11926-020-00891-x |
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To describe the recent advances in the field towards the prevention and early recognition of Psoriatic Arthritis (PsA).
Recent Findings
Defining the preclinical phase of PsA remains challenging since up to 50% of subjects with psoriasis have subclinical imaging enthesopathy, but many of these do not progress to PsA. Nevertheless, there is evidence that subjects with subclinical imaging enthesopathy are at increased risk of developing PsA. In recent years, it has been shown that both PsA and anti-citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA) are characterized by a subclinical phase of non-specific or brief duration arthralgia with shared imaging features accounting for joint symptomatology. Sonographically determined tenosynovitis and enthesitis are the key imaging features present in non-specific PsO arthralgia that are at risk of future PsA development. Furthermore, the early phases of PsA are complicated by factors including body mass index (BMI), which is a risk factor for PsA, but BMI is also associated with imaging abnormalities on enthesopathy. Fully disentangling these clinical and imaging factors will be important for enrichment for imminent PsA so that disease prevention strategies can be investigated.
Summary
Psoriasis patients with arthralgia have a higher prevalence of tenosynovitis and imaging enthesopathy is at higher risk of transitioning to overt PsA.</description><identifier>ISSN: 1523-3774</identifier><identifier>EISSN: 1534-6307</identifier><identifier>DOI: 10.1007/s11926-020-00891-x</identifier><identifier>PMID: 32418006</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arthralgia ; Arthritis, Psoriatic - diagnostic imaging ; Diagnostic Imaging ; Enthesopathy ; Humans ; Medicine ; Medicine & Public Health ; Psoriasis - diagnostic imaging ; Psoriatic Arthritis (JU Scher ; Psoriatic Arthritis (JU Scher, Section Editor) ; Rheumatology ; Section Editor ; Topical Collection on Psoriatic Arthritis</subject><ispartof>Current rheumatology reports, 2020-05, Vol.22 (6), p.24-24, Article 24</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-580e419956245eeece69ab6d0e6f02f49468becb28dd1282c3a4be42f600f57d3</citedby><cites>FETCH-LOGICAL-c512t-580e419956245eeece69ab6d0e6f02f49468becb28dd1282c3a4be42f600f57d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32418006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zabotti, Alen</creatorcontrib><creatorcontrib>Tinazzi, Ilaria</creatorcontrib><creatorcontrib>Aydin, Sibel Zehra</creatorcontrib><creatorcontrib>McGonagle, Dennis</creatorcontrib><title>From Psoriasis to Psoriatic Arthritis: Insights from Imaging on the Transition to Psoriatic Arthritis and Implications for Arthritis Prevention</title><title>Current rheumatology reports</title><addtitle>Curr Rheumatol Rep</addtitle><addtitle>Curr Rheumatol Rep</addtitle><description>Purpose of Review
To describe the recent advances in the field towards the prevention and early recognition of Psoriatic Arthritis (PsA).
Recent Findings
Defining the preclinical phase of PsA remains challenging since up to 50% of subjects with psoriasis have subclinical imaging enthesopathy, but many of these do not progress to PsA. Nevertheless, there is evidence that subjects with subclinical imaging enthesopathy are at increased risk of developing PsA. In recent years, it has been shown that both PsA and anti-citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA) are characterized by a subclinical phase of non-specific or brief duration arthralgia with shared imaging features accounting for joint symptomatology. Sonographically determined tenosynovitis and enthesitis are the key imaging features present in non-specific PsO arthralgia that are at risk of future PsA development. Furthermore, the early phases of PsA are complicated by factors including body mass index (BMI), which is a risk factor for PsA, but BMI is also associated with imaging abnormalities on enthesopathy. Fully disentangling these clinical and imaging factors will be important for enrichment for imminent PsA so that disease prevention strategies can be investigated.
Summary
Psoriasis patients with arthralgia have a higher prevalence of tenosynovitis and imaging enthesopathy is at higher risk of transitioning to overt PsA.</description><subject>Arthralgia</subject><subject>Arthritis, Psoriatic - diagnostic imaging</subject><subject>Diagnostic Imaging</subject><subject>Enthesopathy</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Psoriasis - diagnostic imaging</subject><subject>Psoriatic Arthritis (JU Scher</subject><subject>Psoriatic Arthritis (JU Scher, Section Editor)</subject><subject>Rheumatology</subject><subject>Section Editor</subject><subject>Topical Collection on Psoriatic Arthritis</subject><issn>1523-3774</issn><issn>1534-6307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EoqXwAiyQl2wC1z9xEhZIVUVhpEp0UdaW49xkXCX2YHuq8hS8Mg4zVEVCrOyr851zLR9CXjN4xwCa94mxjqsKOFQAbceq-yfklNVCVkpA83S9c1GJppEn5EVKt1BIaMVzciK4ZC2AOiU_L2NY6HUK0ZnkEs3hOGRn6XnM2-iySx_oxic3bXOi48pvFjM5P9Hgad4ivYmmyNmt4z_91PihmHazs2bFSkyIj-TriHfoV-UleTaaOeGr43lGvl1-urn4Ul19_by5OL-qbM14ruoWULKuqxWXNSJaVJ3p1QCoRuCj7KRqe7Q9b4eB8ZZbYWSPko8KYKybQZyRj4fc3b5fcLBlezSz3kW3mPhDB-P034p3Wz2FO91wASDaEvD2GBDD9z2mrBeXLM6z8Rj2SXMJsmCNWlF-QG0MKUUcH9Yw0GuT-tCkLv3o303q-2J68_iBD5Y_1RVAHIBUJD9h1LdhH335tP_F_gJEL66V</recordid><startdate>20200516</startdate><enddate>20200516</enddate><creator>Zabotti, Alen</creator><creator>Tinazzi, Ilaria</creator><creator>Aydin, Sibel Zehra</creator><creator>McGonagle, Dennis</creator><general>Springer US</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200516</creationdate><title>From Psoriasis to Psoriatic Arthritis: Insights from Imaging on the Transition to Psoriatic Arthritis and Implications for Arthritis Prevention</title><author>Zabotti, Alen ; Tinazzi, Ilaria ; Aydin, Sibel Zehra ; McGonagle, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-580e419956245eeece69ab6d0e6f02f49468becb28dd1282c3a4be42f600f57d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arthralgia</topic><topic>Arthritis, Psoriatic - diagnostic imaging</topic><topic>Diagnostic Imaging</topic><topic>Enthesopathy</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Psoriasis - diagnostic imaging</topic><topic>Psoriatic Arthritis (JU Scher</topic><topic>Psoriatic Arthritis (JU Scher, Section Editor)</topic><topic>Rheumatology</topic><topic>Section Editor</topic><topic>Topical Collection on Psoriatic Arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zabotti, Alen</creatorcontrib><creatorcontrib>Tinazzi, Ilaria</creatorcontrib><creatorcontrib>Aydin, Sibel Zehra</creatorcontrib><creatorcontrib>McGonagle, Dennis</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current rheumatology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zabotti, Alen</au><au>Tinazzi, Ilaria</au><au>Aydin, Sibel Zehra</au><au>McGonagle, Dennis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From Psoriasis to Psoriatic Arthritis: Insights from Imaging on the Transition to Psoriatic Arthritis and Implications for Arthritis Prevention</atitle><jtitle>Current rheumatology reports</jtitle><stitle>Curr Rheumatol Rep</stitle><addtitle>Curr Rheumatol Rep</addtitle><date>2020-05-16</date><risdate>2020</risdate><volume>22</volume><issue>6</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><artnum>24</artnum><issn>1523-3774</issn><eissn>1534-6307</eissn><abstract>Purpose of Review
To describe the recent advances in the field towards the prevention and early recognition of Psoriatic Arthritis (PsA).
Recent Findings
Defining the preclinical phase of PsA remains challenging since up to 50% of subjects with psoriasis have subclinical imaging enthesopathy, but many of these do not progress to PsA. Nevertheless, there is evidence that subjects with subclinical imaging enthesopathy are at increased risk of developing PsA. In recent years, it has been shown that both PsA and anti-citrullinated protein antibodies (ACPA) positive rheumatoid arthritis (RA) are characterized by a subclinical phase of non-specific or brief duration arthralgia with shared imaging features accounting for joint symptomatology. Sonographically determined tenosynovitis and enthesitis are the key imaging features present in non-specific PsO arthralgia that are at risk of future PsA development. Furthermore, the early phases of PsA are complicated by factors including body mass index (BMI), which is a risk factor for PsA, but BMI is also associated with imaging abnormalities on enthesopathy. Fully disentangling these clinical and imaging factors will be important for enrichment for imminent PsA so that disease prevention strategies can be investigated.
Summary
Psoriasis patients with arthralgia have a higher prevalence of tenosynovitis and imaging enthesopathy is at higher risk of transitioning to overt PsA.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32418006</pmid><doi>10.1007/s11926-020-00891-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Arthralgia Arthritis, Psoriatic - diagnostic imaging Diagnostic Imaging Enthesopathy Humans Medicine Medicine & Public Health Psoriasis - diagnostic imaging Psoriatic Arthritis (JU Scher Psoriatic Arthritis (JU Scher, Section Editor) Rheumatology Section Editor Topical Collection on Psoriatic Arthritis |
title | From Psoriasis to Psoriatic Arthritis: Insights from Imaging on the Transition to Psoriatic Arthritis and Implications for Arthritis Prevention |
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