Mother and Embryo Cross-Communication

Endometrial receptivity is a biosensor for embryo quality, as embryos with reduced developmental potential are rejected. However, embryo quality only accounts for an estimated one-third of implantation failures, with suboptimal endometrial receptivity accounting for the remaining two-thirds. As preg...

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Bibliographic Details
Published in:Genes 2020-03, Vol.11 (4), p.376
Main Authors: Idelevich, Anna, Vilella, Felipe
Format: Article
Language:English
Subjects:
Biomarkers
Biosensors
Cell Communication
Cell cycle
Communication
Cytokines
Embryo, Mammalian - cytology
Embryo, Mammalian - physiology
Embryos
Endometrium
Female
Fetuses
Gestation
Hormones
Humans
Implantation
In vitro fertilization
Infertility
Kinases
Maternal-Fetal Exchange
Menstruation
Metabolome
Metabolomics
Mothers
Paracrine signalling
Pregnancy
Proteome
Proteomics
Review
Success
Transcriptome
Uterus
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Summary:Endometrial receptivity is a biosensor for embryo quality, as embryos with reduced developmental potential are rejected. However, embryo quality only accounts for an estimated one-third of implantation failures, with suboptimal endometrial receptivity accounting for the remaining two-thirds. As pregnancy progresses, a uterus continues to engage in close communication with an embryo/fetus, exchanging information in the form of endocrine, paracrine, and other cues. Given the long mammalian gestation period, this dialogue is intricate, diverse, and, currently, not fully understood. Recent progress and the availability of high-throughput techniques, including transcriptomics, proteomics, and metabolomics, has allowed the simultaneous examination of multiple molecular changes, enhancing our knowledge in this area. This review covers the known mechanisms of mother-embryo cross-communication gathered from animal and human studies.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11040376