Finding Opportunities from Surprises and Failures. Development of Rhodium-Stabilized Donor/Acceptor Carbenes and Their Application to Catalyst-Controlled C–H Functionalization

Catalyst-controlled C–H functionalization by means of the C–H insertion chemistry of rhodium carbenes has become a powerful synthetic method. The key requirements for the development of this chemistry are donor/acceptor carbenes and the chiral dirhodium tetracarboxylate catalysts. This perspective w...

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Bibliographic Details
Published in:Journal of organic chemistry 2019-10, Vol.84 (20), p.12722-12745
Main Author: Davies, Huw M. L
Format: Article
Language:English
Subjects:
Catalysis
Methane - analogs & derivatives
Methane - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Stereoisomerism
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Summary:Catalyst-controlled C–H functionalization by means of the C–H insertion chemistry of rhodium carbenes has become a powerful synthetic method. The key requirements for the development of this chemistry are donor/acceptor carbenes and the chiral dirhodium tetracarboxylate catalysts. This perspective will describe the stages involved in developing this chemistry and illustrate the scope of the donor/acceptor carbene C–H functionalization.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.9b02428