Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC re...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2020-05, Vol.26 (18), p.2126-2137
Main Authors: Qiu, Li-Wei, Liu, Yi-Fei, Cao, Xiao-Qing, Wang, Yan, Cui, Xiao-Hong, Ye, Xian, Huang, Shuo-Wen, Xie, Hong-Jun, Zhang, Hai-Jian
Format: Article
Language:English
Subjects:
Animals
Annexin A2 - metabolism
Biomarkers, Tumor - metabolism
Carcinogenesis - immunology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Disease Models, Animal
Disease Progression
Gene Expression Regulation, Neoplastic - immunology
Humans
Liver - immunology
Liver - pathology
Liver Neoplasms - genetics
Liver Neoplasms - immunology
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Opinion Review
Prognosis
Rats
T-Lymphocytes, Regulatory - immunology
Tumor Escape
Tumor Microenvironment - immunology
Up-Regulation
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Summary:Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.
ISSN:1007-9327
2219-2840
DOI:10.3748/WJG.V26.I18.2126