COVID‐19 infection in children and adolescents with cancer in Madrid

• Published in: Pediatric Blood & Cancer 2020-07, Vol.67 (7), p.e28397-n/a
• Main Authors: de Rojas, Teresa, Pérez‐Martínez, Antonio, Cela, Elena, Baragaño, Marta, Galán, Victor, Mata, Cristina, Peretó, Alba, Madero, Luis
• Format: Article
• Language: English
• Subjects: Adolescent; Antiviral Agents - therapeutic use; Asymptomatic; Betacoronavirus; Child; Child, Preschool; Coronavirus Infections - complications; Coronavirus Infections - drug therapy; COVID-19; Female; Hematology; Hospitalization - statistics & numerical data; Humans; Hydroxychloroquine - therapeutic use; Infant; Length of Stay; Letter to the Editor; Letters to the Editor; Male; Neoplasms - complications; Neoplasms - virology; Oncology; Pandemics; Pediatrics; Pneumonia, Viral - complications; Pneumonia, Viral - drug therapy; Prevalence; Risk Factors; SARS-CoV-2; Spain
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.28397

Main characteristics of the patients Age (years) Gender Baseline disease Disease status CT interruption COVID‐19 symptoms Chest X‐ray COVID‐19 treatment 16.5 M NHL Active No Fever hypoxemia Pneumonia HCQ, Tocilizumab, Lopinavir, Ritonavir, Azithromycin, Oxygen support 8 M B‐ALL CR No Fever coughing Pneumonia HCQ 10.6 M B‐ALL CR No Fever Normal HCQ 0.6 M HR‐NBL R/R Yes Asymptomatic – – 12.9 M Myelo‐dysplastic syndrome CR Yes Throat pain Peribronchial cuffing – 12.7 M B‐ALL CR No Fever Peribronchial cuffing HCQ 9 M T‐ALL CR Yes Fever Peribronchial cuffing HCQ, remdesivir 6.8 M Melanoma R/R Yes Coughing Peribronchial cuffing – 11.2 M AML CR No Fever Normal HCQ 6.8 F B‐ALL CR No Coughing, chest pain Pneumonia HCQ 5.2 M B‐ALL CR No Fever Normal HCQ 14.6 M T‐ALL Active No Asymptomatic Normal HCQ 18.6 M Ewing sarcoma R/R Yes Fever, cough, hypoxemia Pneumonia HCQ, azithromycin, corticoids, oxygen support 11 M Wilms tumor R/R No Fever, cough Normal HCQ 3 M B‐ALL CR Yes Fever, cough Normal – Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloblastic leukemia; CR, complete remission; CT, chemotherapy; HCQ, hydroxychloroquine; HR‐NBL, high‐risk neuroblastoma; NHL, non‐Hodgkin lymphoma; R/R, refractory/relapse. [...]it provides an accurate estimation of the real incidence for this patient population, as both the total number of susceptible patients and the total number of infected patients are well known. [...]we believe the accuracy of the calculated infection prevalence among pediatric oncology patients to be notably reliable, as opposed to estimations in the general pediatric population or in other subpopulations.