Peptides Mimicking the β7/β8 Loop of HIV‑1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors

A conformationally constrained short peptide designed to target a protein–protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.

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Bibliographic Details
Published in:ACS medicinal chemistry letters 2020-05, Vol.11 (5), p.811-817
Main Authors: Sánchez-Murcia, Pedro A, de Castro, Sonia, García-Aparicio, Carlos, Jiménez, M. Angeles, Corona, Angela, Tramontano, Enzo, Sluis-Cremer, Nicolas, Menéndez-Arias, Luis, Velázquez, Sonsoles, Gago, Federico, Camarasa, María-José
Format: Article
Language:English
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Letter
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Summary:A conformationally constrained short peptide designed to target a protein–protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.9b00623