Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coronary syndrome (ACS). The purpose of the present study was to investigate Netrin-1 levels in the earl...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-04, Vol.12 (4), p.e7741-e7741
Main Authors: Mutlu, Huseyin, Akilli, Nazire, Cander, Basar, Köylü, Öznur, Gul, Murat, Köylü, Ramazan
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Biomarkers
Cardiology
Emergency Medicine
Medical diagnosis
Medical imaging
Medical prognosis
Mortality
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Summary:Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coronary syndrome (ACS). The purpose of the present study was to investigate Netrin-1 levels in the early diagnosis and successful reperfusion of ACS. Method The study was conducted with 188 patients diagnosed with ACS and 50 healthy subjects at the emergency unit in a prospective design. Blood samples were collected from the patient group at initial admission and after angiography. The control group consisted of healthy adult subjects without any disease. Netrin-1 levels were studied in both groups. Results The Netrin-1 levels of the patient group at the time of admission were found to be higher than of the control group (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7741