Necrotizing enterocolitis and its association with the neonatal abstinence syndrome

OBJECTIVE: The purpose of this study was to describe an identified association between necrotizing enterocolitis (NEC) and prenatal opioid exposure with neonatal abstinence syndrome (NAS) in late preterm and full-term neonates. STUDY DESIGN: In this single-center retrospective cohort study, we analy...

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Bibliographic Details
Published in:Journal of neonatal-perinatal medicine 2020-04, Vol.13 (1), p.81-85
Main Authors: Andrews, L., Davies, T.H., Haas, J., Loudin, S., Heyward, A., Werthammer, J.
Format: Article
Language:English
Subjects:
Analgesics, Opioid - adverse effects
Analgesics, Opioid - blood
Buprenorphine - adverse effects
Buprenorphine - blood
Cohort Studies
Enterocolitis, Necrotizing - epidemiology
Female
Fetal Blood
Gestational Age
Heroin - adverse effects
Heroin - blood
Humans
Infant, Newborn
Infant, Premature
Male
Methadone - adverse effects
Methadone - blood
Neonatal Abstinence Syndrome - epidemiology
Opioid-Related Disorders - epidemiology
Original Research
Pregnancy
Pregnancy Complications - epidemiology
Retrospective Studies
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Summary:OBJECTIVE: The purpose of this study was to describe an identified association between necrotizing enterocolitis (NEC) and prenatal opioid exposure with neonatal abstinence syndrome (NAS) in late preterm and full-term neonates. STUDY DESIGN: In this single-center retrospective cohort study, we analyzed inborn neonates with the diagnosis of NEC discharged from 2012 through 2017. We compared infants with NEC > 35 weeks’ gestation to those with NEC 35 weeks at birth and 14 (61%)  35 weeks had a higher birth weight, earlier onset of symptoms, and a higher percentage of prenatal exposure to opioids compared to those  35 weeks.
ISSN:1934-5798
1878-4429
DOI:10.3233/NPM-180154