Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling

To increase fitness, animals use both internal and external states to coordinate reproductive behaviors. The molecular mechanisms underlying this coordination remain unknown. Here, we focused on pheromone-sensing Or47b neurons, which exhibit age- and social experience-dependent increase in pheromone...

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Bibliographic Details
Published in:Science advances 2020-05, Vol.6 (21), p.eaba6913-eaba6913
Main Authors: Zhao, Songhui, Deanhardt, Bryson, Barlow, George Thomas, Schleske, Paulina Guerra, Rossi, Anthony M, Volkan, Pelin C
Format: Article
Language:English
Subjects:
Animals
Chromatin - genetics
Courtship
Drosophila - metabolism
Drosophila melanogaster - physiology
Drosophila Proteins - metabolism
Hormones
Male
Molecular Biology
Nerve Tissue Proteins - genetics
Neurophysiology
Perception
Pheromones
SciAdv r-articles
Sexual Behavior, Animal - physiology
Transcription Factors - metabolism
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Summary:To increase fitness, animals use both internal and external states to coordinate reproductive behaviors. The molecular mechanisms underlying this coordination remain unknown. Here, we focused on pheromone-sensing Or47b neurons, which exhibit age- and social experience-dependent increase in pheromone responses and courtship advantage in males. Fruitless (Fru ), a master regulator of male courtship behaviors, drives the effects of social experience and age on Or47b neuron responses and function. We show that simultaneous exposure to social experience and age-specific juvenile hormone (JH) induces chromatin-based reprogramming of expression in Or47b neurons. Group housing and JH signaling increase expression in Or47b neurons and active chromatin marks at promoter. Conversely, social isolation or loss of JH signaling decreases expression and increases repressive marks around promoter. Our results suggest that promoter integrates coincident hormone and pheromone signals driving chromatin-based changes in expression and ultimately neuronal and behavioral plasticity.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.aba6913