In Vivo Antimalarial Evaluation of Crude Extract, Solvent Fractions, and TLC-Isolated Compounds from Olea europaea Linn subsp. cuspidata (Oleaceae)

Malaria is a major global public health problem caused by Plasmodium parasites. Drug resistance is becoming a great challenge. New drugs with novel mechanism of action are urgently required. In malarious countries, medicinal plants are commonly used for malaria treatment. Olea europaea is traditiona...

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Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-12
Main Authors: Sibhat, Gereziher Gebremedhin, Hailu, Gebremedhin Solomon, Rajeshwar, Yarra, Hailesilase, Gebretekle Gebremichael, Bitew, Helen
Format: Article
Language:English
Subjects:
Albinism
Antimalarial activity
Antimalarial agents
Antiparasitic agents
Antiprotozoal agents
Bark
Butanol
Chloroquine
Drug dosages
Drug resistance
Investigations
Malaria
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Mosquitoes
Olea europaea
Parasite resistance
Parasites
Public health
Solvents
Thin-layer chromatography
Toxicity
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Summary:Malaria is a major global public health problem caused by Plasmodium parasites. Drug resistance is becoming a great challenge. New drugs with novel mechanism of action are urgently required. In malarious countries, medicinal plants are commonly used for malaria treatment. Olea europaea is traditionally used against malaria in Ethiopia. The aim of this study was to isolate and evaluate antimalarial activity of chemical constituents extracted from Olea europaea against chloroquine-sensitive Plasmodium berghei-infected mice. Stem bark of Olea europaea was extracted with 80% methanol and fractionated with three solvents. The butanol fraction was subjected to isolation with preparative thin-layer chromatography (PTLC). Acute oral toxicity studies were conducted in mice as per the Organization for Economic Co-operation and Development (OECD) guideline 425. Antimalarial activities of the test substances were evaluated using Peter’s 4-day suppressive test. The crude extract showed significant (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/6731485