Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)

The unknown immune stimulation by nucleic acid nanoparticles (NANPs) has become one of the major impediments to a broad spectrum of clinical developments of this novel technology. Having evolved to defend against bacterial and viral nucleic acids, mammalian cells have established patterns of recogni...

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Bibliographic Details
Published in:Current opinion in biotechnology 2020-06, Vol.63, p.8-15
Main Authors: Chandler, Morgan, Johnson, Morgan Brittany, Panigaj, Martin, Afonin, Kirill A
Format: Article
Language:English
Subjects:
Animals
Immunity, Innate
Nanoparticles
Nucleic Acids
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Summary:The unknown immune stimulation by nucleic acid nanoparticles (NANPs) has become one of the major impediments to a broad spectrum of clinical developments of this novel technology. Having evolved to defend against bacterial and viral nucleic acids, mammalian cells have established patterns of recognition that are also the pathways through which NANPs can be processed. Explorations into the immune stimulation brought about by a vast diversity of known NANPs have shown that variations in design correlate with variations in immune response. Therefore, as the mechanisms of stimulation are further elucidated, these trends are now being taken into account in the design phase to allow for development of NANPs that are tailored for controlled immune activation or quiescence.
ISSN:0958-1669
1879-0429
1879-0429
DOI:10.1016/j.copbio.2019.10.011