Novel roles of phosphoinositides in signaling, lipid transport, and disease

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular processes and multiple human diseases mediated by misregulation of PPIn signaling. This review will present a timely summa...

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Bibliographic Details
Published in:Current opinion in cell biology 2020-04, Vol.63, p.57-67
Main Authors: Hammond, Gerald R.V., Burke, John E.
Format: Article
Language:English
Subjects:
Biological Transport - physiology
Flippases
GPCR
Humans
Ion channels
Lipid kinases
Lipid signaling
Lipid transfer proteins
Membrane contact sites
Membrane trafficking
Phosphatidylinositol
Phosphatidylinositols - metabolism
Phosphoinositide kinases
Phosphoinositides
PI3P
PI4KB
PI4P
PIK3CA
PIP2
PIP3
Signal Transduction
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Summary:Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular processes and multiple human diseases mediated by misregulation of PPIn signaling. This review will present a timely summary of recent discoveries in PPIn biology, specifically their role in regulating unexpected signaling pathways, modification of signaling outcomes downstream of integral membrane proteins, and novel roles in lipid transport. This has revealed new roles of PPIns in regulating membrane trafficking, immunity, cell polarity, and response to extracellular signals. A specific focus will be on novel opportunities to target PPIn metabolism for treatment of human diseases, including cancer, pathogen infection, developmental disorders, and immune disorders.
ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2019.12.007