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Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec
Symptoms of Staphylococcus lugdunensis infection are often similar to those of Staphylococcus aureus infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections, S. lugdunensis is regarded as a less important pathogen than drug-r...
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Published in: | Scientific reports 2020-05, Vol.10 (1), p.8682-8682, Article 8682 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Symptoms of
Staphylococcus lugdunensis
infection are often similar to those of
Staphylococcus aureus
infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections,
S. lugdunensis
is regarded as a less important pathogen than drug-resistant
S. aureus
. To investigate its ability to cause infectious diseases, a methicillin-resistant
S. lugdunensis
(MRSL) strain JICS135 was isolated from a patient with bacteremia and subjected to whole genome sequencing. Similar to most strains of methicillin-resistant
S. aureus
(MRSA), this MRSL strain possessed the staphylococcal cassette chromosome
mec
(SCC
mec
) located close to the origin of replication. However, the SCC
mec
in this MRSL strain, with three
ccr
complexes, was structurally unique and currently untypable. Moreover, the SCC
mec
of this MRSL strain was found to carry two genes encoding microbial surface components recognizing adhesive matrix molecules (MSCRAMM)-like proteins accompanied by glycosyl transferases, one of which may have been derived from
S. aureus
and the other from
S. epidermidis
, indicating that this MRSL evolved to carry virulence factors from other staphylococci. The emergence of this strain, the first MRSL strain whose genome has been sequenced completely, may be of public concern. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-020-65632-7 |