Mesenchymal stem cells in the fight against viruses: Face to face with the invisible enemy

The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for a large number of therapeutic applications. I...

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Bibliographic Details
Published in:Current research in translational medicine 2020-08, Vol.68 (3), p.105-110
Main Authors: Sleem, Aleen, Saleh, Fatima
Format: Article
Language:English
Subjects:
Animals
Betacoronavirus - physiology
Cell Culture Techniques
Clinical trials
Coronavirus Infections - immunology
Coronavirus Infections - therapy
Coronavirus Infections - virology
COVID-19
Hepatitis B virus
Hepatitis B virus - physiology
HIV
HIV - physiology
Humans
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal Stem Cell Transplantation - trends
Mesenchymal stem cells (MSCs)
Mesenchymal Stem Cells - physiology
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - therapy
Pneumonia, Viral - virology
SARS-CoV-2
Virus Diseases - epidemiology
Virus Diseases - immunology
Virus Diseases - therapy
Virus Physiological Phenomena
Viruses - pathogenicity
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Summary:The relative ease of isolation of mesenchymal stem cells (MSCs) from different tissues coupled with their culture expansion in vitro and their differentiation capacity to mesodermal, endodermal and ectodermal lineages have made these cells attractive for a large number of therapeutic applications. In recent years, there has been remarkable progress in the utilization of MSCs in diverse clinical indications both in animal models and human clinical trials. However, the potential of MSCs to control or treat viral diseases is still in its infancy. In this study, we report quantitative data on the MSC-based clinical trials over the last ten years as they appear on the online database of clinical research studies from US National Institutes of Health. In particular, we provide comprehensive review of either completed or ongoing clinical trials using MSCs for virus-associated diseases focusing on HIV, hepatitis B virus and COVID-19 virus.
ISSN:2452-3186
2452-3186
DOI:10.1016/j.retram.2020.04.003