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Trypanocidal and leishmanicidal activity of six limonoids
Six limonoids [kotschyienone A and B ( 1 , 2 ), 7-deacetylgedunin ( 3 ), 7-deacetyl-7-oxogedunin ( 4 ), andirobin ( 5 ) and methyl angolensate ( 6 )] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma brucei and promastigotes of Leishmania m...
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Published in: | Journal of natural medicines 2020-06, Vol.74 (3), p.606-611 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Six limonoids [kotschyienone A and B (
1
,
2
), 7-deacetylgedunin (
3
), 7-deacetyl-7-oxogedunin (
4
), andirobin (
5
) and methyl angolensate (
6
)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of
Trypanosoma brucei
and promastigotes of
Leishmania major
. Whereas all compounds showed anti-trypanosomal activity, only compounds
1–4
displayed anti-leishmanial activity. The 50% growth inhibition (GI
50
) values for the trypanocidal and leishmanicidal activity of the compounds ranged between 2.5 and 14.9 μM. Kotschyienone A (
1
) was found to be the most active compound with a minimal inhibition concentration (MIC) value of 10 μM and GI
50
values between 2.5 and 2.9 μM. Only compounds
1
and
3
showed moderate cytotoxicity against HL-60 cells with MIC and GI
50
values of 100 μM and 31.5–46.2 μM, respectively. Compound
1
was also found to show activity against intracellular amastigotes of
L. major
with a GI
50
value of 1.5 μM. The results suggest that limonoids have potential as drug candidates for the development of new treatments against trypanosomiasis and leishmaniasis. |
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ISSN: | 1340-3443 1861-0293 |
DOI: | 10.1007/s11418-020-01408-7 |