SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective

In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more than 5 million people in almost every country in the world, dominating the concern of most governments and public health systems. The social and political distresses caused by this epidemic will certainly impac...

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Published in:Infection, genetics and evolution genetics and evolution, 2020-10, Vol.84, p.104384-104384, Article 104384
Main Authors: Sironi, Manuela, Hasnain, Seyed E., Rosenthal, Benjamin, Phan, Tung, Luciani, Fabio, Shaw, Marie-Anne, Sallum, M. Anice, Mirhashemi, Marzieh Ezzaty, Morand, Serge, González-Candelas, Fernando
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2
Animals
Asia - epidemiology
Betacoronavirus - classification
Betacoronavirus - genetics
Betacoronavirus - pathogenicity
Biological Coevolution
Chiroptera - virology
Coevolution
Coronavirus
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - transmission
COVID-19
Disease Outbreaks
Europe - epidemiology
Eutheria - virology
Gene Expression
Host susceptibility
Host-Pathogen Interactions - drug effects
Host-Pathogen Interactions - genetics
Host-Pathogen Interactions - immunology
Humans
Immune system
Immunity, Innate
Life Sciences
North America - epidemiology
Pandemics
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - immunology
Phylodynamics
Phylogeny
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - transmission
Review
SARS-CoV-2
Severity of Illness Index
Spike Glycoprotein, Coronavirus - antagonists & inhibitors
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
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Summary:In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more than 5 million people in almost every country in the world, dominating the concern of most governments and public health systems. The social and political distresses caused by this epidemic will certainly impact our world for a long time to come. Here, we synthesize lessons from a range of scientific perspectives rooted in epidemiology, virology, genetics, ecology and evolutionary biology so as to provide perspective on how this pandemic started, how it is developing, and how best we can stop it. •A new coronavirus, SARS-CoV-2, emerged by the end of December 2019 in China.•In less than 3 months, it has spread worldwide causing a pandemic of COVID-19.•We review the genetic, virological, ecological, epidemiological and evolutionary factors of this viral pandemic.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2020.104384