Systematic characterization of non‐coding RNAs in triple‐negative breast cancer

Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in...

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Bibliographic Details
Published in:Cell proliferation 2020-05, Vol.53 (5), p.e12801-n/a
Main Authors: Mei, Jie, Hao, Leiyu, Wang, Huiyu, Xu, Rui, Liu, Yan, Zhu, Yichao, Liu, Chaoying
Format: Article
Language:English
Subjects:
Biosynthesis
Breast cancer
Cell cycle
Coding
Cytoplasm
Enzymes
Epidermal growth factor
ErbB-2 protein
Gene expression
Genomes
Growth factors
MicroRNAs
miRNA
Non-coding RNA
Progesterone
Proteins
Receptors
Review
Reviews
RNA polymerase
Roles
Telomerase
Tumorigenesis
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Summary:Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. In this review, we systematically elucidate the general characteristics and biogenesis of miRNAs, lncRNAs and circRNAs, discuss the emerging functions of these ncRNAs in TNBC and present future perspectives in clinical practice.
ISSN:0960-7722
1365-2184
DOI:10.1111/cpr.12801