Remote ischemic preconditioning: Lung protection in the time of a pandemic?

Furthermore, the diverse signals that regulate lung injury, the complex roles of the immune response in balancing repair versus injury, and the absence of a specific antiviral therapy, all suggest that targeting a single molecular pathway may be insufficient in attenuating disease severity. Overall,...

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Bibliographic Details
Published in:Journal of clinical anesthesia 2020-11, Vol.66, p.109920-109920, Article 109920
Main Author: Camara-Lemarroy, Carlos R.
Format: Article
Language:English
Subjects:
Correspondence
Intensive care
Oxidative stress
Pathophysiology
Severe acute respiratory syndrome coronavirus 2
Ventilators
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Summary:Furthermore, the diverse signals that regulate lung injury, the complex roles of the immune response in balancing repair versus injury, and the absence of a specific antiviral therapy, all suggest that targeting a single molecular pathway may be insufficient in attenuating disease severity. Overall, REIP is able to attenuate pro-inflammatory responses, up-regulate anti-inflammatory signals, reduce oxidative stress, regulate the expression of genes that are conductive to tissue repair, among other effects [3]. [...]REIPs protective effects in conditions other than ischemic-injury have also been studied. Any study involving REIP in SARS-CoV-2-associated ARDS should therefore carried out in the context of an ethically reviewed clinical trial.Funding/financial support The writing of this manuscript did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Declaration of competing interest No competing interests to declare.Acknowledgment None.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2020.109920