Remote ischemic preconditioning: Lung protection in the time of a pandemic?

• Published in: Journal of clinical anesthesia 2020-11, Vol.66, p.109920-109920, Article 109920
• Main Author: Camara-Lemarroy, Carlos R.
• Format: Article
• Language: English
• Subjects: Correspondence; Intensive care; Oxidative stress; Pathophysiology; Severe acute respiratory syndrome coronavirus 2; Ventilators
• ISSN: 0952-8180; 1873-4529
• DOI: 10.1016/j.jclinane.2020.109920

Furthermore, the diverse signals that regulate lung injury, the complex roles of the immune response in balancing repair versus injury, and the absence of a specific antiviral therapy, all suggest that targeting a single molecular pathway may be insufficient in attenuating disease severity. Overall, REIP is able to attenuate pro-inflammatory responses, up-regulate anti-inflammatory signals, reduce oxidative stress, regulate the expression of genes that are conductive to tissue repair, among other effects [3]. [...]REIPs protective effects in conditions other than ischemic-injury have also been studied. Any study involving REIP in SARS-CoV-2-associated ARDS should therefore carried out in the context of an ethically reviewed clinical trial.Funding/financial support The writing of this manuscript did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Declaration of competing interest No competing interests to declare.Acknowledgment None.