Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

The urea functionality is inherent to numerous bioactive compounds, including a variety of clinically approved therapies. Urea containing compounds are increasingly used in medicinal chemistry and drug design in order to establish key drug–target interactions and fine-tune crucial drug-like properti...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry 2020-03, Vol.63 (6), p.2751-2788
Main Authors: Ghosh, Arun K, Brindisi, Margherita
Format: Article
Language:English
Subjects:
Animals
Chemistry, Pharmaceutical - methods
Drug Design
Drug Discovery - methods
Humans
Models, Molecular
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The urea functionality is inherent to numerous bioactive compounds, including a variety of clinically approved therapies. Urea containing compounds are increasingly used in medicinal chemistry and drug design in order to establish key drug–target interactions and fine-tune crucial drug-like properties. In this perspective, we highlight physicochemical and conformational properties of urea derivatives. We provide outlines of traditional reagents and chemical procedures for the preparation of ureas. Also, we discuss newly developed methodologies mainly aimed at overcoming safety issues associated with traditional synthesis. Finally, we provide a broad overview of urea-based medicinally relevant compounds, ranging from approved drugs to recent medicinal chemistry developments.
ISSN:0022-2623
1520-4804
DOI:10.1021/acs.jmedchem.9b01541