Constitutive TSH receptor activation as a hallmark of thyroid autonomy

Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. In particular, hyperthyroidism due to autoimmune disease or thyroid autonomy is linked with TSHR activation via autoantibodies or mutations respectivel...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2020-05, Vol.68 (2), p.274-278
Main Author: Führer, Dagmar
Format: Article
Language:English
Subjects:
Autoantibodies
Autoimmune diseases
Autonomy
Cell proliferation
Clinical aspects
Diabetes
Endocrinology
Humanities and Social Sciences
Hyperthyroidism
Internal Medicine
Medicine
Medicine & Public Health
Mini Review
multidisciplinary
Mutation
Receptor mechanisms
Science
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyroid-stimulating hormone receptors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Since its cloning more than 30 years ago, the thyrotropin receptor (TSHR) has emerged as a pivotal player in thyroid physiology and pathophysiology. In particular, hyperthyroidism due to autoimmune disease or thyroid autonomy is linked with TSHR activation via autoantibodies or mutations respectively. This review summarises clinical aspects of constitutive TSH receptor activation by naturally occurring somatic or germline TSHR mutations resulting in TSH-independent thyroid function and cell proliferation.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02270-z