Elevations of serum cancer biomarkers correlate with severity of COVID‐19

In this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID‐19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6 ± 38.3 vs 46.5 ± 14.7 pmol/L;...

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Bibliographic Details
Published in:Journal of Medical Virology 2020-10, Vol.92 (10), p.2036-2041
Main Authors: Wei, Xiuqi, Su, Jingyu, Yang, Kunyu, Wei, Jiazhou, Wan, Huimin, Cao, Xiaoling, Tan, Wenbin, Wang, Hui
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antigens
Antigens, Neoplasm - blood
Antigens, Tumor-Associated, Carbohydrate - blood
Biomarkers
Biomarkers, Tumor - blood
C-Reactive Protein - analysis
CA-125 Antigen - blood
Cancer
cancer biomarker
carbohydrate antigens
Carbohydrates
Carcinoembryonic antigen
Case-Control Studies
China
Comorbidity
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
Cytokeratin
cytokeratin‐19 fragment
Epididymis
epididymis protein 4
Female
Humans
Keratin-19 - blood
Male
Middle Aged
Progressions
Proteins
Retrospective Studies
SARS‐COV‐2
Serpins - blood
Severity of Illness Index
Squamous cell carcinoma
Viral diseases
Virology
WAP Four-Disulfide Core Domain Protein 2 - analysis
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Summary:In this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID‐19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6 ± 38.3 vs 46.5 ± 14.7 pmol/L; P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25957